Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Temporal profile of germ-free and conventionally raised male mice (DUODENUM and ILEUM)

ABSTRACT: Temporal profile of germ-free and conventionally raised male mice (DUODENUM and ILEUM)

PROVIDER: PRJNA471298 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7161280_1.fastq.gz	Fastqsanger.gz
	SRR7161280_2.fastq.gz	Fastqsanger.gz
	SRR7161290_1.fastq.gz	Fastqsanger.gz
	SRR7161290_2.fastq.gz	Fastqsanger.gz
	SRR7161300_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 752

Similar Datasets

Temporal profile of germ-free and conventionally raised male mice (DUODENUM and ILEUM)

Project description:Gut microbiota and the circadian clock both regulate metabolism. The circadian clock and associated feeding rhythms were shown to impact on the microbial community. However, to what extent gut microbiota reciprocally affect daily rhythms of gene expression and physiology in the host remains elusive. Here, we analyzed the transcriptomes of male and female germ-free mice. While this revealed subtle changes in circadian clock gene expression in liver, intestine, and white adipose tissue, germ-free mice showed considerably altered expression of genes associated to rhythmic physiology. Strikingly, absence of microbiome severely compromised liver sex-dimorphism at the transcriptome and metabolome level. Their sex-specific rhythmicity was strongly attenuated. The resulting feminization of male and masculinization of female hepatic gene expression in germ-free animals is likely caused by altered sex-dimorphism in sex and growth hormone secretion, linked to differential activation of xenobiotic receptors. This defines a novel mechanism by which the gut microbiome regulates host metabolism.

2018-09-01 | GSE114399 | GEO

Transcriptional profiling of 77 tissue samples from germ-free and conventionally raised mice.

2011-12-08 | GSE17438 | GEO

Transcriptional profiling of 53 tissue samples from germ-free and conventionally raised mice

2014-01-31 | GSE31115 | GEO

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice.

2011-03-15 | GSE27950 | GEO

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice. 12 samples were analyzed, with 6 germfree (GF) samples vs. 6 conventionally raised (CONV) samples.

2011-03-15 | E-GEOD-27950 | biostudies-arrayexpress

Transcriptional profiling of 53 tissue samples from germ-free and conventionally raised mice

Project description:Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Three different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CONV-R, 4 WT GF, 6 Myd88 -/- GF) and expression profiles were determines using the Affymetrix Mouse Gene 1.0ST platform.

2014-01-31 | E-GEOD-31115 | biostudies-arrayexpress

Temporal profiles of germ-free and conventionally raised female and male mice (LIVER)

Project description:Temporal profiles of germ-free and conventionally raised female and male mice (LIVER)

| PRJNA471297 | ENA

RNA-seq of mouse small intestinal epithelial cells sorted from duodenum, jejunum and ileum

Project description:Results of RNA-seq of normal C57BL/6 small intestinal epithelial cells sorted from duodenum, jejunum and ileum separately. Samples are named as follow; mouse replicate number-duodenum(1), jejunum(2) or ileum(3). For example, 1-1, 1-2 and 1-3 representing duodenum, jejunum and ileum respectively from mouse replicate number 1.

2021-01-21 | E-MTAB-9744 | biostudies-arrayexpress

Temporal profile of germ-free and conventionally raised male mice (epididymal white adipose tissue (WAT))

Project description:Temporal profile of germ-free and conventionally raised male mice (epididymal white adipose tissue (WAT))

| PRJNA471296 | ENA

Transcriptional profiling of intestinal tissue samples from germ-free and conventionally raised mice which are either wild-type or Myd88-/-

Project description:Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Four different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CONV-R, 4 WT GF, 6 Myd88 -/- GF) and expression profiles were determines using the Affymetrix Mouse Gene 1.0ST platform. 77 samples remained after quality control.

2011-12-08 | E-GEOD-17438 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data