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Mus musculus

ABSTRACT: Transcriptome or Gene Expression of Mouse Brain Induced by Toxoplasma gondii Oocysts

PROVIDER: PRJNA483261 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7657880_1.fastq.gz	Fastqsanger.gz
	SRR7657880_2.fastq.gz	Fastqsanger.gz
	SRR7657881_1.fastq.gz	Fastqsanger.gz
	SRR7657881_2.fastq.gz	Fastqsanger.gz
	SRR7657872_1.fastq.gz	Fastqsanger.gz

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mus musculus

Project description:MicroRNA expression of mouse brain induced by Toxoplasma gondii oocysts

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Gene expression analysis of Hammondia hammondi and Toxoplasma gondii sporulated oocysts

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Gene expression analysis of Hammondia hammondi and Toxoplasma gondii sporulated oocysts

Project description:To date little is known about the transcriptome of Hammondia hammondi, the nearest extant relative of Toxoplasma gondii. In this study we used an existing microarray to query Toxoplasma gondii and Hammondia hammondi transcript abundance in sporulated oocysts. Oocysts of the VEG strain of Toxoplasma gondii, and the HhCatGer041 strain of Hammondia hammondi, were isolated from cat feces by sucrose flotation, and sporulated for ~3-6 months in 2% sulfuric acid. RNA was isolated from Bleach-treated oocyst preparations using the Trizol reagent. RNA was biotinylated for hybridization to Toxo 169 Affymetrix chips using the Illumina Total Prep RNA labeling kit (Ambion). For each species 3 separate RNA isolations were performed on the same batch of oocysts and hybridized to individual microarrays.

2014-10-02 | E-GEOD-61963 | biostudies-arrayexpress

Acetylated proteome analysis of changes in the mouse brain tissue infected with Toxoplasma gondii oocysts during the acute and chronic stage

Project description:The mice were acutely and chronically infected with Toxoplasma gondii oocysts, and the mouse brain tissue was obtained, and the total protein was extracted, proteolysed, and enriched for acetylated polypeptides.

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Mus musculus cultivar:129S2/SvPasCrl

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Transcriptomics of Toxoplasma gondii sporulating oocysts

Project description:Transcriptomics of Toxoplasma gondii sporulating oocysts

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Transcriptomics of Toxoplasma gondii sporulating oocysts

Project description:Toxoplasma gondii is an apicomplexan parasite that approximately infects one third of the human population worldwide. When sporulated oocysts that are shed in the faeces of infected felids are accidentally ingested through contaminated food or water, sporozoites can infect the intestine of the intermediate host. Upon this infection, the fast replicating tachyzoites then disseminate overall the body and can cross the blood-brain, blood-retina or the blood-placenta barrier. Eventually, immune pressure will lead to differentiation into the slow replicating bradyzoites that are contained within tissue cysts for life. Despite the importance of sporulation for transmission, the process is not yet understood. We therefore exploited Illumina Next-Generation RNA-Sequencing to analyse the transcriptome of oocysts in the process of sporulation and compared it to unsporulated and sporulated oocysts. We thus identified genes that are highly specific to the sporulation process and that may be involved in the formation of sporozoites.

2022-06-20 | GSE206344 | GEO

Mus musculus

Project description:Transcriptional profile of brain TRM in Toxoplasma gondii infection

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Toxoplasma gondii infection supports the infiltration of T cells into brain tumors

Project description:Primary brain tumors, residing behind the blood-brain-barrier (BBB), have few infiltrated T cells. We hypothesized that Toxoplasma gondii, a microorganism that naturally traffics to the brain to elicit a Th1 response, can promote T cell infiltration into brain tumors. Using a mouse genetic model for medulloblastoma, we found that T. gondii infection was well-controlled in tumor-bearing mice, induced robust infiltration of T cells into the tumor, and led to myeloid cell transcriptional reprogramming toward a T cell-supportive state. The study demonstrates that the immune modulatory capacity of T. gondii could be leveraged to promote brain tumor immunotherapy through future efforts.

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Transcriptomics of Toxoplasma gondii enteroepithelial stages

Project description:Toxoplasma gondii is a zoonotic pathogen for which felids serve as definitive hosts. In cats, the parasite undergoes several rounds of asexual replication before entering the sexual cycle which gives rise to oocysts that are shed into the environment. These then sporulate and become infective to humans and live stock. To understand the genes involved in the parasite development in the felid host and identify potential intervention targets, we designed a transcriptomic approach to compare the cat intestinal stages with the well characterised tachyzoites that mediate acute infection and tissue cysts that are responsible for chronic infection. Cats were infected with T. gondii tissue cysts from mouse brain and sampled the intestinal stages at day 3, 5 and 7 post infection. As an input sample, we also collected tissue cysts from mouse brain as well as in vitro cultivated tachyzoites. Total RNA was extracted, enriched for mRNA and used for cDNA synthesis. RNA-Seq was then performed to describe the transcriptomic repertoire of each time point/life cycle stage.

2018-03-30 | GSE108740 | GEO

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