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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) [Hep1-6]

ABSTRACT: RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) [Hep1-6]

PROVIDER: PRJNA512625 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8387970_1.fastq.gz	Fastqsanger.gz
	SRR8387970_2.fastq.gz	Fastqsanger.gz
	SRR8387971_1.fastq.gz	Fastqsanger.gz
	SRR8387971_2.fastq.gz	Fastqsanger.gz
	SRR8387972_1.fastq.gz	Fastqsanger.gz

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) [Hep1-6]

Project description:To address how serum cholesterol affected tumor progression, C57BL/6J mice were placed on either normal diet or high cholesterol diet for 4 weeks, and then Hep1-6 cells were subcutaneously injected into the right flanks of mice. We performed transcriptome sequencing analysis (RNA-seq) on tumor tissues from ND and HCD groups.

2019-02-03 | GSE124599 | GEO

RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD)

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) II

Project description:To address how serum cholesterol affected tumor progression, C57BL/6J mice were placed on either normal diet or high cholesterol diet for 4 weeks, and then B16F10 cells were subcutaneously injected into the right flanks of mice. We performed transcriptome sequencing analysis (RNA-seq) on tumor tissues from ND and HCD groups.

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD)

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) II

Project description:RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) II

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The effect of Lats2 knockout and diet on liver disease in mice

Project description:Liver samples of mice harboring liver-specific deletion of Lats2 (Lats2-CKO) were compared to WT mice. This effect was tested along with the effect of diet - high cholesterol diet (Paigen-PD) vs. normal chow (ND). Expression array analysis on Affymetrix microarrays was carried out for livers from WT and Lats2-CKO mice fed ND or HCD for 9 weeks.

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Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

Project description:The vulnerability of bone marrow hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct cholesterol metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with HCD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month HCD treatment.

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Effect of High Cholesterol Diet (HCD) on B cell subsets in atheroprone mice with or without myb deficiency

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Project description:Purpose: To investigate the effects of paternal high cholesterol diet on the F1 intimal transcriptome related to atherosclerosis. Methods:Three-week-old male LDL Receptor-deficient (LDLR-/-) male mice were fed a low-cholesterol diet (LCD) or high-cholesterol diet (HCD) for 8 weeks and then mated with age-matched control LDLR-/- female mice to generate F1 offspring. F1 LDLR-/- mice were fed a LCD for 16 weeks. Intimal RNA was extracted by injecting Trizol into the aorta and collecting the flow through for further processing. Results: . Total RNA isolated from the F1 intima were then subjected for RNA-sequencing analysis and results show that paternal hypercholesterolemia led to upregulation of 147 genes in the intimal of F1 female mice, many of which are involved in immune and inflammatory pathways.

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