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ABSTRACT: Diisononyl phthalate exposure inducing adipocyte differentiation

PROVIDER: PRJNA524766 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8651550.fastq.gz	Fastqsanger.gz
	SRR8651551.fastq.gz	Fastqsanger.gz
	SRR8651552.fastq.gz	Fastqsanger.gz
	SRR8651553.fastq.gz	Fastqsanger.gz

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Project description:Diisononyl phthalate exposure inducing 3T3-L1 preadipocytes differentiation

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Effect of Diisononyl Phthalate on Rat Primary Hepatocytes.

2012-08-28 | GSE40342 | GEO

Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)

Project description:Here, we identified potential protein interaction partners of MINCH, as primary metabolite of the phthalate DEHP substitute DINCH, in the human SGBS adipocyte cell line. This study includes data on the thermal stability of proteins upon incubation of the cell lysates with 10 µM MINCH at day 4, an early, and day 12, the terminal day of adipocyte differentiation.

2025-08-05 | PXD059386 | Pride

Effect of Diisononyl Phthalate on Rat Primary Hepatocytes.

Project description:This study provides an evaluation of changes in gene expression associated with diisononyl phthalate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (25 mM and 100 mM) of diisononyl phthalate and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis. This series is part of a SuperSeries in which primary rat hepatocytes were treated with two doses of ten chemical compounds (and corresponding vehicle controls) for 24 and 48 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported. Time Course/Dose Response

2012-08-28 | E-GEOD-40342 | biostudies-arrayexpress

Prenatal diisononyl phthalate exposure induces the development of pulmonary dysplasia in offspring

Project description:Prenatal diisononyl phthalate exposure induces the development of pulmonary dysplasia in offspring

| PRJNA1398077 | ENA

Toxicogenomic Screen of Replacements for bis(2-ethylhexyl) phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line

Project description:Phthalate plasticizers are being phased out of consumer products because of their endocrine disrupting properties. This has resulted in a need to find safe alternatives that can plasticize polyvinyl chloride (PVC) while being inexpensive and biodegradable. We aim to study the toxicogenomic profile of mono-(2-ethylhexyl) phthalate (MEHP, the active metabolite of bis(2-ethylhexyl) phthalate, DEHP), the commercial plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), and three plasticizers in development (1,4 butanediol dibenzoate (BDB), dioctyl succinate (DOS), and dioctyl maleate (DOM)) using the immortalized TM4 Sertoli cell line.

2015-08-06 | GSE66812 | GEO

Toxicogenomic Screen of Replacements for bis(2-ethylhexyl) phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line

2015-08-06 | E-GEOD-66812 | biostudies-arrayexpress

Hepatotoxicity

Project description:This SuperSeries is composed of the following subset Series: GSE40336: Effect of Acetominophen on Rat Primary Hepatocytes. GSE40337: Effect of Dioctyl Phthalate on Rat Primary Hepatocytes. GSE40338: Effect of Sodium Valproate on Rat Primary Hepatocytes. GSE40339: Effect of Phenobarbital on Rat Primary Hepatocytes. GSE40340: Effect of Beta-Naphthoflavone on Rat Primary Hepatocytes. GSE40341: Effect of Chlorpromazine HCl on Rat Primary Hepatocytes. GSE40342: Effect of Diisononyl Phthalate on Rat Primary Hepatocytes. GSE40344: Effect of Clofibrate on Rat Primary Hepatocytes. GSE40346: Effect of WY-14643 on Rat Primary Hepatocytes. GSE40347: Effect of Methapyrilene on Rat Primary Hepatocytes. Refer to individual Series

2012-08-28 | E-GEOD-40348 | biostudies-arrayexpress

Rattus norvegicus

Project description:Effect of Diisononyl Phthalate on Rat Primary Hepatocytes.

| PRJNA173837 | ENA

Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the female mouse.

Project description:Di(2-ethylhexyl) phthalate (DEHP) is a phthalate commonly used for its plasticizing capabilities. Because of the wide production and use of DEHP, humans are exposed to DEHP on a daily basis. Diisononyl phthalate (DiNP) is often used as a DEHP replacement chemical, and because of the increased use of DiNP, humans are increasingly exposed to DiNP over time. Of concern is that DEHP and DiNP both exhibit endocrine disrupting capabilities, and little is known about how short-term exposure to either of these phthalates affects aspects of female reproduction. Thus, this study tested the hypothesis that short-term exposure to DEHP or DiNP during adulthood has long-lasting consequences on ovarian follicles and hormones in female mice. Female CD-1 mice aged 39–40 days were orally dosed with either vehicle control (corn oil), DEHP (20 μg/kg/day or 200 ug/kg/day), or DiNP (20 μg/kg/day or 100 ug/kg/day) for 10 days. Total ovarian RNA was collected either immediately post-dosing (0 month) or 3 months post-dosing. The results indicate that 10 days of exposure to DEHP and DiNP changed the distribution of ovarian follicle populations and sex steroid hormones both immediatly after treatment as well as 3 months after treatment. These data show that short-term exposure to either DEHP or DiNP has long-term consequences that persist long after cessation of exposure. RNA sequence analysis was preformed to elucidate the ovarian molecular pathways altered by DEHP or DiNP exposure immediatly after treatment or 3 months after treatment.

2026-01-01 | GSE158473 | GEO

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