Dataset Information

Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)

ABSTRACT: Here, we identified potential protein interaction partners of MINCH, as primary metabolite of the phthalate DEHP substitute DINCH, in the human SGBS adipocyte cell line. This study includes data on the thermal stability of proteins upon incubation of the cell lysates with 10 µM MINCH at day 4, an early, and day 12, the terminal day of adipocyte differentiation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Simpson-golabi-behmel Syndrome Type 1

SUBMITTER: Alix Sarah Aldehoff

LAB HEAD: Kristin Schubert

PROVIDER: PXD059386 | Pride | 2025-08-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20240812_AA_TPP_MINCH_SGBS_d4_d12_reviewed.mgf	Mgf
	20240812_AA_TPP_MINCH_SGBS_d4_d12_reviewed.msf	Msf
	20240812_AA_TPP_MINCH_SGBS_d4_d12_reviewed.mzML	Mzml
	20240812_AA_TPP_MINCH_SGBS_d4_d12_reviewed.mzid.gz	Mzid
	20240812_AA_TPP_MINCH_SGBS_d4_d12_reviewed.xlsx	Xlsx

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Publications

Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH.

Aldehoff Alix Sarah AS Karkossa Isabel I Broghammer Helen H Krupka Sontje S Weiner Juliane J Goerdeler Cornelius C Nuwayhid Rima R Langer Stefan S Wabitsch Martin M Rolle-Kampczyk Ulrike U Klöting Nora N Blüher Matthias M Heiker John T JT von Bergen Martin M Schubert Kristin K

Environmental science & technology 20250730

The concept of metabolic disruption through exposure to chemicals has expanded our understanding of how environmental pollution can contribute to metabolic dysregulation and, ultimately, diseases like obesity. New strategies for assessing the risks posed by chemicals are needed, and omics technologies, including proteomics, have proven to be powerful tools for investigating the molecular mechanisms of these metabolism-disrupting chemicals (MDCs). A potential MDC is the plasticizer DINCH─an alter ...[more]

PMID: 40736767

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