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ABSTRACT: Diisononyl phthalate exposure inducing 3T3-L1 preadipocytes differentiation

PROVIDER: PRJNA525006 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8649746.fastq.gz	Fastqsanger.gz
	SRR8649747.fastq.gz	Fastqsanger.gz
	SRR8649748.fastq.gz	Fastqsanger.gz
	SRR8649749.fastq.gz	Fastqsanger.gz

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Project description:Diisononyl phthalate exposure inducing adipocyte differentiation

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Project description:Cebpa is a critical transcription factor gene for adipocyte differentiation and adipose tissue development. However, mechanisms controlling Cebpa expression during adipogenic differentiation remain largely unknown. Here, we generated the high-resolution chromatin interaction maps of Cebpa in 3T3-L1 preadipocytes (3T3-L1) and 3T3-L1 adipocytes (3T3-L1-AD) using circularized chromosome conformation capture coupled with next-generation sequencing (4C-seq), and characterized differences in their chromatin interactomes and chromatin status of the interaction sites during adipogenic differentiation. We performed a 4C-seq experiment on inguinal white adipose tissue (iWAT) to evaluate whether chromatin interaction between Cebpa-L1-AD-En2 and Cebpa promoters in 3T3-L1 adipocytes also exists in mouse adipose tissue.

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