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Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout

ABSTRACT: Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout

PROVIDER: PRJNA548326 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR9268860_1.fastq.gz	Fastqsanger.gz
	SRR9268860_2.fastq.gz	Fastqsanger.gz
	SRR9268861_1.fastq.gz	Fastqsanger.gz
	SRR9268861_2.fastq.gz	Fastqsanger.gz

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Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 2]

Project description:Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 2]

| PRJNA548333 | ENA

Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 1]

Project description:Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 1]

| PRJNA548334 | ENA

Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 2]

Project description:Skin samples from wild type or HIRA knockout mouse embryos were dissociated to give cellular suspensions, then single cell RNA sequencing was performed using the 10X platform. Method: Cellular suspensions of skin cells from wild type and HIRA knockout mice were prepared, then sequencing was performed using the Chromium 10X system. Data were then processed using Cellranger version 2.2.0.

2025-06-11 | GSE132544 | GEO

Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout [dataset 1]

2025-06-11 | GSE132543 | GEO

Single cell RNA Sequencing of murine tdTomato positive skin cells with or without HIRA knockout

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-06-11 | GSE132545 | GEO

Effect of a cardiomyocyte-specific Hira conditional knockout on gene expression in the heart

Project description:We performed gene expression profiling by microarray using RNA extracted from healthy free wall left ventricle tissues from control and Hira cardiomyocyte-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histone variant H3.3 at actively transcribed regions. Conditional knockout of Hira in cardiomyocytes resulted in impaired cardiac function, cardiomyocyte degeneration and focal replacement fibrosis. These results illustrate the role of Hira in controlling the cardiac gene program. 4 animals per group (control and Hira conditional knockout) hybridized in triplicate. RNA was extracted from healthy free wall left ventricle.

2016-04-06 | E-GEOD-71833 | biostudies-arrayexpress

Single-cell RNA sequencing of mouse myeloid cardiac tdTomato+ and tdTomato- cells (Fgd5-CreERT2) post-myocardial infarction upon DMSO and 4-oxo-RA treatment.

Project description:This lineage tracing experiment focused on studying the transcriptome of cardiac myeloid cells derived from BM HSCs post-MI. We performed Left coronary artery ligation (LAD) in a tamoxifen-inducible in vivo HSC-lineage tracing mouse model which allows HSC-progeny lineage tracing via Tomato expression (Fgd5-CreERT2 tdTomato; PMID: 30561324). This was followed by a 2-day treatment with either vehicle (DMSO) or 4-oxo-RA. On day 3 post-MI, hearts were extracted, and tdTomato-positive and tdTomato-negative myeloid cells (CD11b+) were isolated from the myocardium. scRNA-seq was performed.

2025-02-06 | E-MTAB-13580 | biostudies-arrayexpress

Expression data and HIRA ChIP-seq data from interferon treated IMR90 cells

Project description:IMR90 cells treated with IFN and without IFN, with and without a lentivirus knockdown of HIRA

2018-01-09 | GSE74863 | GEO

Effect of a cardiomyocyte-specific Hira conditional knockout on gene expression in the heart

2016-04-06 | GSE71833 | GEO

HIRA regulate Arabidopsis dedifferentiation process

Project description:Plant development is characterised by the capacity to reprogram differentiated cells to initiate asexual reproduction and to produce new organs such as lateral roots. To test whether HIRA could be involved in aspects of developmental reprogramming we studied the effect of HIRA during de-differentiation Arabidopsis root tissue was digested with enzyme to generate protoplast. This process would induce plant cell dedifferentiation. Experiments were performed in WT and hira background to understand how hira affect plant dedifferentiation process.

2014-10-01 | E-GEOD-57044 | biostudies-arrayexpress

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