Project description:Purpose: The goals of this study are to compare CD1 background spermatogonia veh with NRRA treatment transcriptome profiling (RNA-seq) and to evaluate protocols for in vitro induced meiosis system.Methods: CD1 background spermatogonia mRNA profiles of veh and NRRA treatment were generated by deep sequencing, in duplicate. Methods: CD1 background spermatogonia veh with NRRA treatment were generated by deep sequencing, in duplicate. Conclusions: Our study represents the first detailed analysis of induced meiosis spermatogonia transcriptomes, with biologic replicates, generated by RNA-seq technology.
Project description:We explored the relationship between the evolutionary dynamics of CTCF binding and the functional stability of higher order genome structures, by performing ChIP-seq experiments in closely related Mus species or strains and intersecting with Hi-C-derived topologically associating domains (TADs) and expression data. Experiments were performed in adult male liver samples, using input control sets.
