Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: Peroxisome elevation induces stem cell differentiation and intestinal epithelial repair

PROVIDER: PRJNA563469 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10076559_1.fastq.gz	Fastqsanger.gz
	SRR10076559_2.fastq.gz	Fastqsanger.gz
	SRR10076560_1.fastq.gz	Fastqsanger.gz
	SRR10076560_2.fastq.gz	Fastqsanger.gz
	SRR10076561_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Drosophila melanogaster

Project description:Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

| PRJNA686687 | ENA

Drosophila melanogaster

Project description:Gene expression in intestinal stem cells

| PRJNA252363 | ENA

Drosophila melanogaster

Project description:Stonewalling Drosophila stem cell differentiation by epigenetic controls

| PRJNA99355 | ENA

Drosophila melanogaster

Project description:A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders

| PRJNA143407 | ENA

Gall&Pin2022 - ODE model of the intestinal epithelium

Project description:We developed a compartmental model of the small intestinal epithelium that describes stem and progenitor cell proliferation and differentiation and cell migration onto the villus. The model includes a negative feedback loop from villus cells to regulate crypt proliferation and integrates heterogeneous epithelial-related processes, such as the transcriptional profile, citrulline kinetics and probability of diarrhea. This is an updated version that includes improvements made to the model following the original publication, that will be included in upcoming publications.

2025-09-11 | MODEL2212120003 | BioModels

Drosophila melanogaster

Project description:Tis11 mediated mRNA degradation regulates intestinal stem cell quiescence in Drosophila melanogaster

| PRJNA381000 | ENA

Drosophila melanogaster

Project description:ClC-c regulates intestinal stem cell proliferation via EGFR signaling pathway in Drosophila

| PRJNA748595 | ENA

Tis11 mediated mRNA degradation regulates intestinal stem cell quiescence in Drosophila melanogaster

Project description:we show that Tis11, an Adenine-uridine Rich Element (ARE) binding protein that promotes mRNA degradation, is required to re-establish basal proliferation rates of adult Drosophila intestinal stem cells (ISC) after a regenerative episode. We find that Tis11 limits ISC proliferation specifically after proliferation has been stimulated in response to heat stress or infection, and show that Tis11 expression and activity are increased in ISCs during tissue repair. Based on stem cell transcriptome analysis and RNA immunoprecipitation, we propose that Tis11 activation represents an integral part of a negative feedback mechanism that limits the expression of key components of several signaling pathways that control ISC function and proliferation. Our results identify Tis11 mediated mRNA decay as an evolutionarily conserved mechanism of re-establishing basal proliferation rates of stem cells in regenerating tissues.

2017-09-05 | GSE97216 | GEO

Drosophila melanogaster

Project description:Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

| PRJNA379553 | ENA

Drosophila melanogaster

Project description:Alpha-lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction

| PRJNA579055 | ENA