Project description:The purpose of this study was to investigate gene expression in SIDS cases and controls, in order to uncover genes that are differentially expressed in the two groups. Tissue from brain, heart and liver from 15 SIDS cases and 15 controls were included in this study, and mRNA expression was determined using the Illumina whole genome gene expression DASL HT assay
Project description:The purpose of this study was to investigate gene expression in SIDS cases and controls, in order to uncover genes that are differentially expressed in the two groups. Tissue from brain, heart and liver from 15 SIDS cases and 15 controls were included in this study, and mRNA expression was determined using the Illumina whole genome gene expression DASL HT assay WGDASL_HT ASSAY 15018210_D
Project description:Primary outcome(s): Relationship with mRNA expression of B7 family molecules in blood of patients with colorectal cancer and clinicopathological factors
Project description:Sudden infant death syndrome (SIDS) may involve impaired cerebellar contributions to autonomic and arousal responses during hypoxic stress. We performed bulk RNA sequencing of flash-frozen postmortem human cerebellar cortex from SIDS infants and age-matched non-SIDS controls to define transcriptional alterations associated with SIDS. Differential-expression and pathway-enrichment analyses were used to evaluate neuroinflammatory, neurotransmitter, and metabolic programs, and transcriptomic findings were compared at the pathway level with independently generated targeted metabolomics and quantitative histology data.
