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CD48-dependent protective autophagy in conventional human T cells promotes restimulation-induced cell death resistance

ABSTRACT: CD48-dependent protective autophagy in conventional human T cells promotes restimulation-induced cell death resistance

PROVIDER: PRJNA573899 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10173731_1.fastq.gz	Fastqsanger.gz
	SRR10173731_2.fastq.gz	Fastqsanger.gz
	SRR10173732_1.fastq.gz	Fastqsanger.gz
	SRR10173732_2.fastq.gz	Fastqsanger.gz
	SRR10173733_1.fastq.gz	Fastqsanger.gz

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CD48-dependent protective autophagy in conventional human T cells promotes restimulation-induced cell death resistance

Project description:Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48, which in turn sustains basal autophagy and suppresses pro-apoptotic p53 signaling. Our findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.

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Project description:Rattus norvegicus Cd48, Cd48 molecule [Source:RGD Symbol;Acc:620620], is differentially expressed in 47 experiment(s);

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Project description:Rattus norvegicus Cd48, Cd48 molecule [Source:RGD Symbol;Acc:620620], is expressed in 6 baseline experiment(s);

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Project description:Sus scrofa CD48, CD48 molecule [Source:VGNC Symbol;Acc:VGNC:86419], is differentially expressed in 1 experiment(s);

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Project description:Homo sapiens CD48, CD48 molecule [Source:HGNC Symbol;Acc:HGNC:1683], is expressed in 31 baseline experiment(s);

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Project description:Sus scrofa CD48, CD48 molecule [Source:VGNC Symbol;Acc:VGNC:86419], is expressed in 3 baseline experiment(s);

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