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The potential role of long noncoding RNAs in primary open angle glaucoma

ABSTRACT: The potential role of long noncoding RNAs in primary open angle glaucoma

PROVIDER: PRJNA574677 | ENA |

REPOSITORIES: ENA

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The potential role of long noncoding RNAs in primary open angle glaucoma

Project description:Long non-coding RNAs were associated with the development and progression of glaucoma. Our study aim to identify the potential genes in human trabecular meshwork related to primary open-angle glaucoma (POAG).

2019-09-28 | GSE138125 | GEO

Expression profiling of extracellular long noncoding RNAs in aqueous humor of primary open-angle glaucoma patients

Project description:Long noncoding RNAs (lncRNAs) are emerging as important regulators in cellular processes and have been showed to be involved in the occurrence and development of various neurodegenerative diseases including glaucoma. The aim of this study is to reveal disease-related extracellular lncRNAs and message RNAs (mRNAs) in aqueous humor (AH) of individual primary open-angle glaucoma (POAG) patients, to determine the potential biomarkers for POAG diagnosis

2018-12-18 | GSE101727 | GEO

Construction of miRNA-mRNA Regulatory Network Indicates Potential Biomarkers for Primary Open-Angle Glaucoma

Project description:MicroRNAs were associated with the development and progression of glaucoma. Our study aims to identify the potential miRNAs and target genes in human trabecular meshwork related to primary open-angle glaucoma (POAG).

2023-05-05 | GSE231760 | GEO

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

Project description:To better understand the molecular changes in the aqueous humor (AH) content with glaucoma, we analyzed the microRNA (miRNA) profiles of AH samples from patients with Primary Open Angle Glaucoma (POAG) and Exfoliation Glaucoma (XFG) compared to non-glaucoma controls.

2018-02-08 | GSE105269 | GEO

The Primary Open-Angle Glaucoma Genetics Study (POAAGG)

Project description:The Primary Open-Angle Glaucoma Genetics Study (POAAGG)

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Construction of miRNA-mRNA Regulatory Network Indicates Potential Biomarkers for Primary Open-Angle Glaucoma

Project description:Construction of miRNA-mRNA Regulatory Network Indicates Potential Biomarkers for Primary Open-Angle Glaucoma

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Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

Project description:Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

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Dysregulated proteins in aqueous humor from primary open angle glaucoma patients with clinical correlation

Project description:Primary open angle glaucoma (POAG) presents as an irreversible optic neuropathy with corresponding visual field deficits and no other notable symptoms. The pathophysiology of POAG remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. This enables us to better understand pathological changes in POAG from a molecular perspective, and may reveal potential diagnostic molecular biomarkers in POAG. We are also interested in correlating differences in AH protein compositions with demographics and clinical severity in POAG patients.

2024-05-23 | PXD033153 | Pride

The potential role of long noncoding RNAs in primary open-angle glaucoma.

Project description:PurposeTo identify the potential genes in human trabecular meshwork (TM) related to primary open-angle glaucoma (POAG).MethodsFirst, long noncoding RNA (LncRNA) and mRNA expression profiles in TM samples from 4 control subjects and 4 POAG patients were accessed by microarray analyses. Then, twenty lncRNAs were validated by real-time quantitative PCR in the same samples from microarray analyses. Finally, eight highly expressed lncRNAs were further tested by real-time quantitative PCR in TM from 8 normal controls and 19 POAG patients. Expression data were normalized and analyzed using the R software. Pathway analyses were performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.ResultsA total of 2179 lncRNAs and 923 mRNAs in the TM of POAG patients were significantly upregulated, and 3111 lncRNAs and 887 mRNAs were significantly downregulated. ENST00000552367, ENST00000582505, ENST00000609130, NR_029395, NR_038379, and ENST00000586949 expression levels were significantly higher in the TM from a different cohort of POAG patient than normal controls.ConclusionENST00000552367, ENST00000582505, ENST000006091- 30, NR_029395, NR_038379, and ENST00000586949 may play essential roles in the development of POAG.

| S-EPMC8589759 | biostudies-literature

A quantitative spectral library of human aqueous humor was analyzed using TimsTOFTM Pro Bruker for primary open angle glaucoma (POAG).

Project description:Globally, irreversible vision loss is mainly attributed to glaucoma, a complex eye condition. Given that the progression of glaucoma is challenging to detect and track, and reliable predictive markers are lacking, there is an urgent need for biomarkers. In this context, the aqueous humor, which is part of the anterior segment of the eye, assumes a critical role. The aim of this study is to develop a comprehensive database for glaucoma research by analyzing primary open-angle glaucoma (POAG) human aqueous humor samples (n=66). We employ advanced label-free quantitative proteomics to investigate the proteome associated with glaucoma in human aqueous humor. Our dataset, generated using the TimsTOF™ Pro Bruker mass spectrometer and DIA-NN bioinformatics for library-independent quantification of data-independent acquisition (DIA) proteomics, offers researchers access to the most extensive catalog of human aqueous humor proteins reported to date. This resource is expected to deepen our understanding of the proteomic profiles in human glaucoma aqueous humor and also support investigations into proteomes related to other ocular conditions.

2025-08-04 | PXD060484 | Pride

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