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Single cell transcriptional atlas of mouse Achilles tendons

ABSTRACT: Single cell transcriptional atlas of mouse Achilles tendons

PROVIDER: PRJNA576229 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10239195.fastq.gz	Fastqsanger.gz
	SRR10239196.fastq.gz	Fastqsanger.gz
	SRR10239197.fastq.gz	Fastqsanger.gz
	SRR10239198.fastq.gz	Fastqsanger.gz

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Single cell transcriptional atlas of mouse Achilles tendons

Project description:We report a single cell transcriptome atlas of Achilles tendon from 6-week-old male C57Bl/6 mice using single cell RNA sequencing.

2019-10-10 | GSE138515 | GEO

Expression data from post-natal rat Achilles tendons

Project description:We have compared the gene expression profile of post-natal 1 day and 7 day rat Achilles tendons. Post-natal 1 day and 7 day rat Achilles tendons were collected. Each sample contains at least two individuals. Total RNA was extracted and fragmented biotin-tagged cRNA was hybridized to Rat Genome 230 2.0 Array.

2015-07-10 | E-GEOD-70459 | biostudies-arrayexpress

Expression data from post-natal rat Achilles tendons

Project description:We have compared the gene expression profile of post-natal 1 day and 7 day rat Achilles tendons.

2015-07-10 | GSE70459 | GEO

Transcriptional analysis of tendons from rat

Project description:We report RNA sequencing data from the Achilles, patellar, supraspinatus, and forepaw flexor tendons of adult male rats in the Sprague-Dawley

2019-12-18 | GSE138540 | GEO

Transcriptional analysis of tendons from mice

Project description:We report RNA sequencing data from the Achilles, patellar, supraspinatus, and forepaw flexor tendons of adult male mice in the C57Bl/6 background.

2019-12-18 | GSE138537 | GEO

Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties

Project description:The purpose of this project is to determine changes in proteins and signaling pathways in injured tendons of C57BL/6j and MRL/MpJ mice. The MRL.MpJ mice have been reported to have a strong repair ability compared to that of C57BL/6j mice. Identifying signaling pathways in MRL/MpJ tendons that are distinct from C57BL/6j tendons will help us understand the molecular mechanisms underlying the better healing ability of MRL/MpJ mice. The samples include normal and injured Achilles tendons 4 weeks after tenotomy surgery obtained from male and female C57BL/6j and MRL/MpJ. The Achilles injury surgery was performed at 12 weeks of age. Normal tendons were obtained age, sex and strain-matched mice without surgery. The collected normal and inured tendons were subjected to proteomics.

2025-05-16 | PXD057712 | Pride

Regional transcriptomics and mechanical properties of rat Achilles tendons

Project description:Regional transcriptomics and mechanical properties of rat Achilles tendons

| PRJNA796046 | ENA

Regional transcriptomics and mechanical properties of rat Achilles tendons

Project description:The transcriptome of different tendons varies based on anatomical location and is likely influenced by the biomechanical loading environment. While differences in biologic and mechanical properties of whole tendons have been assessed, less is understood about differences within a tendon along its proximal-distal axis. Therefore, our objective was to determine the characteristics of and relationship between the transcriptomes and mechanical properties of a single tendon.

2022-11-03 | GSE193408 | GEO

Structure-function Relationships in Human Tendons: Interfascicular Matrix Specialisation in the Achilles Tendon C4PR_LIV

Project description:Tendon is a highly aligned connective tissue, in which the macro-structure consists of collagen-rich fascicles surrounded by interfascicular matrix (IFM). In a series of recent studies in equine tissue, we have demonstrated specialisation of tendon composition, structure and mechanics to achieve the tendon’s functional requirements, specifically reporting extensive specialisation of the IFM region in the energy storing superficial digital flexor tendon. We have also demonstrated loss of functional specialisms with ageing, leading to a hypothesised new paradigm for tendinopathy, focused on the importance of the IFM. However, to date, there have been no studies focused on structure-function specialisation or the IFM in functionally distinct human tendons. Here, we compare the positional anterior tibialis tendon and energy storing Achilles tendon, performing a detailed analysis of the composition and mechanical properties of both fascicle and IFM regions, to test the hypothesis that the IFM in the energy storing Achilles tendon has specialised composition and mechanical properties, and that these specialisations are lost with ageing. We demonstrate that the IFM is specialised in the energy storing Achilles tendon, with greater elasticity and fatigue resistance than in the positional anterior tibialis tendon. While there were few age-related alterations in mechanics, we did identify age-related alterations in the IFM proteome of the Achilles tendon specifically, which is predicted to be regulated by TGF-beta signalling and may be responsible for the trend towards decreased fatigue resistance observed in the Achilles IFM with ageing.

2020-11-11 | PXD018212 | Pride

Effects of running for 1h on gene expression in Achilles tendon cells of SD rats

Project description:The Achilles tendon is the thickest tendon in the human body, and Achilles tendinopathy is its most prevalent disorder, often considered a consequence of overuse. While disruption to the collagen fibers represents a significant manifestation of Achilles tendinopathy, strikingly little is known about the mechanisms by which healthy tendon accumulates damage in vivo.As existing studies of tendon biomechanics and mechanobiology predominantly relied on in vitro or ex vivo experiments on isolated tissues, it is still largely unknown whether and how disruptions occur to the collagen molecules in healthy Achilles tendons following physiological activities. We reported the first RNA-seq analysis reflecting transcriptome changes in healthy rat Achilles tendons following running, providing a resource for future investigations in tendon mechanobiology and sports medicine.

2024-10-07 | GSE269529 | GEO

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