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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

ABSTRACT: Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

PROVIDER: PRJNA605736 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11051271.fastq.gz	Fastqsanger.gz
	SRR11051272.fastq.gz	Fastqsanger.gz
	SRR11051273.fastq.gz	Fastqsanger.gz
	SRR11051274.fastq.gz	Fastqsanger.gz
	SRR11051275.fastq.gz	Fastqsanger.gz

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]

Project description:Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [meDIP-seq]

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

Project description:The emerging role of epigenetic mechanisms like DNA methylation executed by DNA methyltransferases (DNMTs) in synaptic function irrevocably raises the question for the targeted subcellular processes and mechanisms. We here sequenced FAC-sorted PVergic interneurons of 6 month and 18month old PV-Cre/tdTomato/Dnmt1loxp wildtype and knockout mice and performed RNA-Seq and MeDIP-Seq.

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]

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Expression data from 18-month old rats

Project description:Expression data from 18-month old rats

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Project description:The development of cortical circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned and vital process during brain development. Aberrations affecting the establishment of these circuits are implicated in several neuropsychiatric and neurological disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in the development and migration of post-mitotic somatostatin-positive interneurons as well as its impact on the rest of the cortical population.

2025-06-18 | GSE298336 | GEO

Dnmt1 deletion in Hmx3-positive POA-derived interneurons

Project description:Dnmt1 deletion in Hmx3-positive POA-derived interneurons

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Spatial transcriptomics of 3-month-old and 18-month-old mouse ovarian and uterine tissues

Project description:We used Visium technology (10X Genomics) to infer cell-to-cell communication in ovarian and uterine tissue based on spatial proximity. Organs from 3-month mice in diestrus and 18-month old mice were collected and frozen in OCT. 10 µm thick tissue slices were placed on Visium Spatial Gene Expression Slides (10X Genomics) and stained with Hematoxylin and Eosin (H&E). Libraries were prepared by manufacturer’s recommendations and sequenced on NovaSeq6000. For samples that were sequenced in two runs, both sequencing runs were merged when running spaceranger (10X Genomics). Original nd2 microscopy images and results of scRNA-seq (linked datasets) and spatial transcriptomics analysis are available at Biostudies (S-BIAD482 and S-BSST852).

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2025-07-30 | GSE300332 | GEO

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