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Transcriptional analysis of isolated intestinal epithelial cells (IEC) from adult infected and age-matched control animals

ABSTRACT: Transcriptional analysis of isolated intestinal epithelial cells (IEC) from adult infected and age-matched control animals

PROVIDER: PRJNA623023 | ENA |

REPOSITORIES: ENA

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Transcriptional analysis of isolated intestinal epithelial cells (IEC) from adult infected and age-matched control animals

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proteomic analysis of serum samples of 11 biliary stresia pateints and 9 age matched healthy controls

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Expression data from colon samples from FADD IEC-KO (intestinal epithelial cell-knock out) and CASP8 IEC-KO mice in combination with different genetic mutations (Zbp1 -/-, Mlkl -/-, Ripk3 IEC-KO)

Project description:FADD-IEC KO and CASP8 IEC-KO mice spontaneously develop chronic colitis charcterized by inflammatory gene expression. We characterized the role of MLKL, RIPK3, ZBP1, in the upregulation of inlflammatory genes in these mice. We used microarray to study the effect of MLKL, RIPK3 and ZBP1 on the gene expression profile in FADD IEC-KO and/or CASP8 IEC-KO mice and detect effects on specific inflammatory genes.

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Expression data from ileum samples from FADD IEC-KO (intestinal epithelial cell-knock out) and CASP8 IEC-KO mice in combination with different genetic mutations (Zbp1 -/-, Mlkl -/-, Ripk3 IEC-KO)

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