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Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity

ABSTRACT: Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity

PROVIDER: PRJNA625268 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11542200.fastq.gz	Fastqsanger.gz
	SRR11542201.fastq.gz	Fastqsanger.gz
	SRR11542202.fastq.gz	Fastqsanger.gz
	SRR11541103.fastq.gz	Fastqsanger.gz
	SRR11542203.fastq.gz	Fastqsanger.gz

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Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [RNA-seq]

Project description:Obesity occurs when energy expenditure is outweighed by food intake. Tuberal hypothalamic nuclei, including the arcuate nucleus (ARC), ventromedial nucleus (VMH), and dorsomedial nucleus (DMH), regulate feeding amount as well as energy expenditure. Here we report that mice lacking circadian nuclear receptors REV-ERBa and b in the tuberal hypothalamus (HDKO) gain excessive weight on an obesogenic diet due both to decreased energy expenditure and increased food consumption during the light phase. Moreover, rebound food intake after fasting is markedly increased in HDKO mice. Integrative transcriptomic and cistromic analyses revealed that such disruption in feeding behavior is due to perturbed REV-ERB-dependent leptin signaling in the ARC. Indeed, in vivo leptin sensitivity is impaired in HDKO mice on an obesogenic diet in a circadian manner. Thus, REV-ERBs play a crucial role in hypothalamic regulation of food intake and circadian leptin sensitivity in diet-induced obesity.

2020-10-11 | GSE148641 | GEO

Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [ChIP-seq]

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Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [RNA-seq]

Project description:Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [RNA-seq]

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Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [ChIP-seq]

Project description:Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity [ChIP-seq]

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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Project description:Rev-Erba and Rev-Erbb are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism, and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting NCoR/HDAC3 co-repressor complexes to Rev-Erb response elements in enhancers and promoters of target genes, but the molecular basis for cell-specific programs of repression is not known. Here, we present evidence that in macrophages, Rev-Erbs regulate target gene expression by inhibiting the functions of distal enhancers that are selected by macrophage lineage-determining factors, thereby establishing a macrophage-specific program of repression. Remarkably, the repressive functions of Rev-Erbs are associated with their ability to inhibit the transcription of enhancer-derived RNAs (eRNAs). Furthermore, targeted degradation of eRNAs at two enhancers subject to negative regulation by Rev-Erbs resulted in reduced expression of nearby mRNAs, implying a direct role of these eRNAs in enhancer function. By precisely defining eRNA start sites using a method that quantifies nascent 5' ends (5'-GRO-Seq), we show that transfer of full enhancer activity to a target promoter requires both the sequences mediating transcription factor binding and the specific sequences encoding the eRNA transcript. These studies provide evidence for direct roles of eRNAs in contributing to enhancer functions and suggest that Rev-Erbs act to suppress gene expression at a distance by repressing eRNA transcription. Using ChIPseq, GRO-seq, and 5'GRO-seq to determine mechanism of RevErb in transcriptional regulation in macrophages

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Skeletal muscle Rev-erbs regulates metabolic diurnal rhythm

Project description:Rev-erb plays a pivotal role in coordinating circadian rhythms and in regulating metabolism. However, The regulation of muscle metabolism by Rev-erbs is still not fully understood. In this study, we explored the mechanisms through which Rev-erb regulates skeletal muscle by using ChIP-seq.

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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

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Transcriptome analysis of Rev-erbs skeletal muscle specific knockout muscles and WT muscles

Project description:We used Rev-erbs skeletal muscle specific knockout mouse model to illustrate the Rev-erbs function in skeletal muscle. In this study, transcriptome sequencing was used to detect the mRNA expression profiles of KO muscles and WT muscles.

2025-05-04 | GSE249730 | GEO

Hypothalamic REV-ERBs Control Circadian Food Intake and Leptin Sensitivity

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-11 | GSE148644 | GEO

Tanycyte-independent control of hypothalamic leptin signaling

Project description:Purpose: 1. Bulk-RNA-Seq was performed to identify tancytye-enriched genes. 2. scRNA-Seq was performed to profile hypothalamic cells following leptin treatment Conclusions: Leptin receptor expression in tanycytes is either absent or undetectably low, that tanycytes do not directly regulate hypothalamic leptin signaling, and that leptin regulates gene expression in diverse hypothalamic cell types through both direct and indirect mechanisms.

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