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ABSTRACT: Triazole-resistance in Aspergillus fumigatus

PROVIDER: PRJNA625421 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11548078.fastq.gz	Fastqsanger.gz
	SRR11548079.fastq.gz	Fastqsanger.gz
	SRR11548080.fastq.gz	Fastqsanger.gz
	SRR11548081.fastq.gz	Fastqsanger.gz
	SRR11548082.fastq.gz	Fastqsanger.gz

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Exposure to Tebuconazole Drives Cross-Resistance to Clinical Triazoles in Aspergillus fumigatus

Project description:The emergence of triazole resistance in Aspergillus fumigatus poses a significant threat to clinical antifungal therapy. This study investigated the impact of prolonged exposure to the agricultural triazole tebuconazole (TEB) on the susceptibility of A. fumigatus to clinical triazoles and explored associated resistance mechanisms. After 28 days of exposure, isolates exhibited substantial increases in minimum inhibitory concentrations (MICs): up to 128-fold for itraconazole, 64-fold for posaconazole, and 16-fold for voriconazole. Resistance persisted even after TEB removal. Ergosterol levels remained stable, while efflux pump inhibition led to MIC reduction, confirming their role in resistance. Proteomic analysis identified 193 upregulated and 88 downregulated proteins, with distinct profiles between treated and untreated groups. These findings demonstrate that agricultural triazoles can induce stable, multidrug-resistant phenotypes in A. fumigatus, emphasizing the need for integrated surveillance of antifungal resistance across environmental and clinical settings.

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Project description:Genomic Surveillance of Aspergillus fumigatus Triazole Resistance in the United States

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Project description:Genomic Surveillance of Aspergillus fumigatus Triazole Resistance in the United States

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Use of Bulk Segregant Analysis for Determining the Genetic Basis of Azole Resistance in the Opportunistic Pathogen Aspergillus fumigatus

Project description:Genome sequence data results are reported from experimental and bioinfomatic work using the technique 'Bulk Segregant Analysis' to determine the genetic basis of observed resistance to the azole antifungal compound itraconazole in the opportunistic fungal pathogen Aspergillus fumigatus.

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Project description:Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel triazole-resistance genes

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Comparative genomic hybridization of Aspergillus fumigatus Af71, Aspergillus fumigatus Af294, Aspergillus clavatus, Neosartorya fenneliae and Neosartorya fischeri with Aspergillus fumigatus Af293

Project description:Genomic DNA from five strains, Aspergillus fumigatus Af71, Aspergillus fumigatus Af294, Aspergillus clavatus, Neosartorya fenneliae, and Neosartorya fischeri, were co-hybridized with that of Aspergillus fumigatus Af293 and compared.

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Response of A549 cells treated with Aspergillus fumigatus

Project description:This SuperSeries is composed of the following subset Series: GSE24983: Response of A549 cells treated with Aspergillus fumigatus [WT-CF_vs_WT-GC] GSE24984: Response of A549 cells treated with Aspergillus fumigatus [WT-GC_vs_PrtT-GC] GSE24985: Response of A549 cells treated with Aspergillus fumigatus [WT-CF_vs_PrtT-CF] Refer to individual Series

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Project description:Genomic perspective of triazole resistance in clinical and environmental Aspergillus fumigatus isolates without cyp51A mutations

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The role of Aspergillus fumigatus SmiA transcription factor in the miltefosine resistance

Project description:By searching for new drugs against fungal pathogens, we found that miltefosine is active against Aspergillus fumigatus clinical isolates. A library of transcription factors (TF) null mutants was then challenged with this drug and we discovered a novel TF that confers resistance to miltefonise, named here SmiA. By using ChIP-seq, we searched for SmiA targets upon miltefosine treatment.

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Project description:Aspergillus fumigatus is an important human pathogen and a leading fungal killer. This study aimed to determine the small RNA repertoire of A. fumigatus in conidia and mycelium grown for 24 or 48 hours in liquid culture.

2023-02-14 | GSE223619 | GEO

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