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ABSTRACT: Genomic Surveillance of Aspergillus fumigatus Triazole Resistance in the United States

PROVIDER: PRJNA784551 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11785100_1.fastq.gz	Fastqsanger.gz
	SRR11785100_2.fastq.gz	Fastqsanger.gz
	SRR11785200_1.fastq.gz	Fastqsanger.gz
	SRR11785200_2.fastq.gz	Fastqsanger.gz
	SRR11785101_1.fastq.gz	Fastqsanger.gz

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Project description:Genomic Surveillance of Aspergillus fumigatus Triazole Resistance in the United States

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Exposure to Tebuconazole Drives Cross-Resistance to Clinical Triazoles in Aspergillus fumigatus

Project description:The emergence of triazole resistance in Aspergillus fumigatus poses a significant threat to clinical antifungal therapy. This study investigated the impact of prolonged exposure to the agricultural triazole tebuconazole (TEB) on the susceptibility of A. fumigatus to clinical triazoles and explored associated resistance mechanisms. After 28 days of exposure, isolates exhibited substantial increases in minimum inhibitory concentrations (MICs): up to 128-fold for itraconazole, 64-fold for posaconazole, and 16-fold for voriconazole. Resistance persisted even after TEB removal. Ergosterol levels remained stable, while efflux pump inhibition led to MIC reduction, confirming their role in resistance. Proteomic analysis identified 193 upregulated and 88 downregulated proteins, with distinct profiles between treated and untreated groups. These findings demonstrate that agricultural triazoles can induce stable, multidrug-resistant phenotypes in A. fumigatus, emphasizing the need for integrated surveillance of antifungal resistance across environmental and clinical settings.

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Use of Bulk Segregant Analysis for Determining the Genetic Basis of Azole Resistance in the Opportunistic Pathogen Aspergillus fumigatus

Project description:Genome sequence data results are reported from experimental and bioinfomatic work using the technique 'Bulk Segregant Analysis' to determine the genetic basis of observed resistance to the azole antifungal compound itraconazole in the opportunistic fungal pathogen Aspergillus fumigatus.

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Project description:Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel triazole-resistance genes

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Effect of amphotericin B on Aspergillus fumigatus

Project description:Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections including invasive aspergillosis. We aimed to understand molecular targets of AMB in Aspergillus fumigatus (Afu) by genomic approaches. Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections including invasive aspergillosis. We aimed to understand molecular targets of AMB in Aspergillus fumigatus (Afu) by microarray and proteomic methods. Keywords: Aspergillus fumigatus treated with amphotericin B for 24 hours Experiment was performed in dye swap manner from two different biological replicates

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