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RNA sequencing of human marcrophages treated with lipopolysaccharide (LPS) for 8 hours, with or without BCAT1 inhibitor (ERG240)

ABSTRACT: RNA sequencing of human marcrophages treated with lipopolysaccharide (LPS) for 8 hours, with or without BCAT1 inhibitor (ERG240)

PROVIDER: PRJNA625455 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11548465_1.fastq.gz	Fastqsanger.gz
	SRR11548465_2.fastq.gz	Fastqsanger.gz
	SRR11548466_1.fastq.gz	Fastqsanger.gz
	SRR11548466_2.fastq.gz	Fastqsanger.gz
	SRR11548467_1.fastq.gz	Fastqsanger.gz

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RNA sequencing of human marcrophages treated with lipopolysaccharide (LPS) for 8 hours, with or without BCAT1 inhibitor (ERG240)

Project description:Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors. In order to study the effect of BCAT1 inhibitor (ERG240) on LPS-polarized macrophage transcriptome, we stimulated monocyte derived macrophages (MDMs) with LPS for 8 hours, with or without the presence of ERG240. We then performed whole-genome transcriptome sequencing by RNA-sequencing (RNA-seq).

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