Project description:In this study, we performed the microarray analysis in two arginine auxotrophic prostate cancer cell lines, 22Rv1 and PC3, to detail the global gene expression with or without arginine condition.
Project description:Gene expression profiling of four prostate cancer cell lines and seven prostate cancer xenografts. The experiment was done to see which genes were over- or underexpressed in the samples. The results were combined with aCGH results of the same samples (experiment prostate cancer CGH) to see, whether the copy number status had any effect on gene expression.
Project description:SChLAP1 is a novel long non-coding RNA expressed in prostate cancer. Here we performed transcriptional profiling of the prostate cancer cell lines LNCaP and 22Rv1 comparing non-targeting siRNA treatment versus SChLAP1-siRNA treatment. Goal was to determine the effect of SChLAP1 knockdown on gene expression in prostate cancer.
Project description:In this study, comparison of gene expression profiles in benign epithelia from men with prostate cancer to those of men without prostate cancer reveal differences in several genes associated with prostate cancer. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile benign epithelium from prostate needle biopsies from 15 men with high grade(Gleason 8-10) prostate cancer and 14 age- and BMI-matched controls. All samples were laser-capture microdissected and total RNA isolated and amplified prior to hybridization against a common reference pool of prostate tumor cell lines