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Epigenome analyses of HCT116 cells stably expressing UHRF1 mutant [Illumina EPIC]

ABSTRACT: Epigenome analyses of HCT116 cells stably expressing UHRF1 mutant [Illumina EPIC]

PROVIDER: PRJNA637514 | ENA |

REPOSITORIES: ENA

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Epigenome analyses of HCT116 cells stably expressing UHRF1 mutant [Illumina EPIC]

Project description:UHRF1 is a key regulator of DNA methylation maintenance. In this study, we investigated whether acetylation of UHRF1 affects its hemimethylated DNA binding affinity and alters genome-wide DNA methylation pattern. We show that cells with mutation in K490 of UHRF1 have distinct methylation profile versus wildtype UHRF1 expressing cells.

2020-06-06 | GSE151862 | GEO

Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

Project description:UHRF1 is a key regulator of DNA methylation maintenance. In this study, we investigated whether acetylation of UHRF1 affects its hemimethylated DNA binding affinity and alters genome-wide DNA methylation pattern. We observed that acetylation of UHRF1 is regulated by HDAC1 and PCAF. We investigated DNA methylation profile of HDAC1 depleted HCT116 cell with control cell.

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EPIC-array 850k data from human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs.

Project description:DNA methylation profiling (Illumina’s Infinium Methylation EPIC Bead Chip v1.0 microarray) were performed in human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs.

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Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

Project description:Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

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Epigenome analysis of HDAC1 stably knocked down HCT116 cells and HCT116 cells stably expressing UHRF1 mutant

Project description:Epigenome analysis of HDAC1 stably knocked down HCT116 cells and HCT116 cells stably expressing UHRF1 mutant

| PRJNA637512 | ENA

EPIC-array 850k data from human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs.

Project description:EPIC-array 850k data from human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs.

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RNA-seq data from human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs.

Project description:transcriptome profiling were performed in human HCT116 wild-type cells, HCT116 DNMT1 hypomorphs, and HCT116 UHRF1 hypomorphs. The paired-end RNA-seq on the Illumina platform was employed to obtain comprehensive gene expression profiles.

2026-04-20 | GSE305298 | GEO

DNA methylation analysis of HCT116 after knockdown and rescue of UHRF1

Project description:In HCT116 colorectal cancer cells, UHRF1 was knocked down by shRNA (puromycin) while simultaneously transduced with wildtype or mutant UHRF1 (blasticidin) or NDI1 (- control) followed by dual antibiotic selection. DNA was analyzed 11 days after viral transduction.

2019-08-14 | GSE135802 | GEO

DNA methylation analysis of HCT116 after knockdown of LIG1, UHRF1, or luciferase (control)

Project description:In HCT116 colorectal cancer cells, UHRF1, LIG1, or luciferase was knocked down by shRNA followed by selection with puromycin for 2 days. DNA was analyzed 12 days after viral transduction.

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Expression data from HeLa cell lines stably expressing shRNA targeting ctrl or UHRF1

Project description:We used microarrays to explore the expression profile from cells expressing wild type and UHRF1 S674A mutant. HeLa cells expressing UHRF1 WT and S674A mutant showed similar gene expression pattern without significant affecting the transcription of DNA repari genes. UHRF1 was depleted in HeLa cells by shRNA treatment. Total RNA was purified and used to determine the global gene transcription profiles by microarray assays. The UHRF1-related genes expression profiles were compared among control cells, UHRF1-depleted cells, UHRF1 WT reconstituting cells and UHRF1 S674A mutant reconstituting cells.

2016-01-05 | E-GEOD-73751 | biostudies-arrayexpress

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