Project description:In the transition from recto-vaginal colonizing organism to invasive pathogen, Streptococcus agalactiae (Group B Streptococcus, GBS) must adapt to changes in host temperature, including elevated temperatures due to host fever. To identify genes important to the survival of GBS in response to heat stress, transcriptional profiling was performed using DNA microarray analysis, comparing GBS grown at normal temperature (37˚C) to GBS exposed to elevated temperature (42˚C).
2012-11-18 | GSE14573 | GEO
Project description:Invasive Group A Streptococcus infections (Streptococcus pyogenes) in Iceland, 2022-2023
| PRJEB62874 | ENA
Project description:Whole-genome sequencing of invasive and non-invasive Group A Streptococcus (GAS)
Project description:Since 2010 a macrolide resistant emm92-type strain of invasive group A Streptococcus has emerged in the United States, posing the question of whether acquired erm(T)-encoded resistance may have contributed to the rise in infections. Here, we present RNA sequencing of the emm92 transcriptome in response to erythromycin exposure.
2025-07-24 | GSE303398 | GEO
Project description:Invasive Group B Streptococcus from Faroe Islands, 2020 - 2024
Project description:The human pathogen Streptococcus pyogenes, or group A streptococcus, is responsible for mild infections to life-threatening diseases. We previously have performed the transcription start site profiling of a Streptococcus pyogenes emm1 strain, strain S119, an invasive strain isolated from a blood culture. Here, we perform strand-specific RNA-seq experiments to complete this characterization and analyze the global coverage and the differential expression in growth medium complemented or not with 15 mM MgCl2. In addition we compare these results to those obtained with a related strain, strain S126, corresponding to a colonization sample, that differs from S119 by only one mutation in the two-component regulator of virulence CovRS.
