Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiling of LNCaP cells following short term shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

ABSTRACT: Gene expression profiling of LNCaP cells following short term shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

PROVIDER: PRJNA693815 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13496880_1.fastq.gz	Fastqsanger.gz
	SRR13496880_2.fastq.gz	Fastqsanger.gz
	SRR13496881_1.fastq.gz	Fastqsanger.gz
	SRR13496881_2.fastq.gz	Fastqsanger.gz
	SRR13496882_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Gene expression profiling of LNCaP cells following shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

Project description:TMEFF2 is an androgen regulated transmembrane protein mainly restricted to brain and prostate, that functions as a tumor suppressor in prostate cancer (PCa). Studies using publically available prostate cancer (PCa) datasets, reveal changes in the expression of TMEFF2 with disease stage, supporting an important role of TMEFF2 in this disease. However, the role of TMEFF2 in the biology and pathogenesis of PCa is still unknown. Using a transgenic TMEFF2 mouse, we have demonstrated that TMEFF2 overexpression modulates prostate branching morphogenesis, and androgen regulated process, during prostate regeneration. We hypothesized that TMEFF2 may have a regulatory function within androgen signaling that could explain its role in PCa. To better understand its function in androgen signaling and PCa, we compared the transcriptome of LNCaP prostate cancer cells transduced with control shRNA and shRNA targeting TMEFF2 in the presence and absence of dihydrotestosterone (DHT). The results indicated that globally, there is a significant interaction between the effects of DHT and shTMEFF2. Of the 519 genes with significant gene expression changes after DHT treatment of Scramble control cells, 208 (40%) had significant differential expression when the shTMEFF2 +DHT group was compared to Scramble +DHT group, including numerous androgen activated and androgen repressed genes.

2019-04-01 | GSE117180 | GEO

Gene expression profiling of LNCaP cells following short term shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

Project description:Analysis of RNA expression in LNCaP cells expressing shTMEFF2 to define its trancriptome. We report global changes in the AR-signaling transcriptome in response to shRNA targeted to TMEFF2.

2021-02-01 | GSE165246 | GEO

Gene expression profiling of LNCaP cells following shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

Project description:Gene expression profiling of LNCaP cells following shRNA-mediated knockdown of TMEFF2 and growth in presence and absence of dihydrotestosterone

| PRJNA481362 | ENA

LNCaP cells: shRNA library with bicalutamide

Project description:Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth Vehicle vs. bicalutamide treated LNCaP cells infected with lentiviral shRNA library. Biological replicates: 2 vehicle treatments, 2 bicalutamide treatments.

2015-05-15 | E-GEOD-60382 | biostudies-arrayexpress

shRNA-mediated knockdown of PRMT5 gene in LNCaP cells

Project description:We performed shRNA-mediated knockdown of PRMT5 in LNCaP cells via dox-inducible expression system. We sought to compare transcriptome with- and without PRMT5 knockdown across three biological replicates

2025-06-13 | GSE206111 | GEO

shRNA-mediated knockdown of MEP50 gene in LNCaP cells

Project description:We performed shRNA-mediated knockdown of MEP50 in LNCaP cells via dox-inducible expression system. We sought to compare transcriptome with- and without MEP50 knockdown across three biological replicates

2025-06-23 | GSE206820 | GEO

shRNA-mediated knockdown of PRMT5 gene in LNCaP cells

Project description:shRNA-mediated knockdown of PRMT5 gene in LNCaP cells

| PRJNA849221 | ENA

shRNA-mediated knockdown of MEP50 gene in LNCaP cells

Project description:shRNA-mediated knockdown of MEP50 gene in LNCaP cells

| PRJNA852249 | ENA

TMEFF2 isoform detection in LNCaP prostate cancer cells

Project description:TMEFF2 isoform detection in LNCaP prostate cancer cells

| PRJNA693813 | ENA

LNCAP in-vitro treatment with androgen receptor targeting drugs

Project description:Gene expression in LNCaP cells after treatment with the androgen receptor targeting drugs bicalutamide (BIC), enzalutamide (ENZ) and apalutamide (ARN) in the presence or absence of dihydrotestosterone (DHT).

2022-09-07 | GSE211781 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data