Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency

ABSTRACT: Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency

PROVIDER: PRJNA694424 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency

Project description:We sorted hematopoietic progenitors from mouse bone marrow previously transplanted with either Csnk1a1 fl/+ or Mx1Cre+ bone marrow and performed scRNAseq. We identified cell populations in a continuum of differentiation from quiescent stem cell to cycling lineage-marker expressing progenitor. Our analysis revealed signaling changes in primitive stem cells with Csnk1a1 haploinsufficiency that result in downregulation of inflammatory NFkB signaling while upregulating Myc and E2f dependent pro-proliferative pathways

2022-02-27 | GSE165395 | GEO

SETD5 haploinsufficiency affects mitochondrial compartment in neural cells

Project description:SETD5 haploinsufficiency affects mitochondrial compartment in neural cells

| PRJNA918428 | ENA

Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

Project description:We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo. We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.

2014-02-23 | E-GEOD-52928 | biostudies-arrayexpress

PRMT1 and CSNK1a1 control epidermal progenitor maintenance (PRMT1/CSNK1a1 transcriptome profiling data sets)

Project description:Here we determine the target gene sets controlled by PRMT1 or CSNK1a1 in maintaining the undifferentiated state of primary human keratinocytes.

2018-02-02 | GSE110049 | GEO

Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

Project description:We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo.

2014-02-23 | GSE52928 | GEO

PRMT1 and CSNK1a1 control epidermal progenitor maintenance (PRMT1/CSNK1a1 transcriptome profiling data sets)

Project description:PRMT1 and CSNK1a1 control epidermal progenitor maintenance (PRMT1/CSNK1a1 transcriptome profiling data sets)

| PRJNA432779 | ENA

Genome-Wide Analysis of Haploinsufficiency in Human Embryonic Stem Cells

Project description:Establishment of a heterozygous genome-wide loss-of-function CRISPR library for studying haploinsufficiency in human embryonic stem cells.

2022-05-02 | E-MTAB-11464 | biostudies-arrayexpress

TMT-based Proteomic and Phosphoproteomic Profiling of Csnk1a1 Wild-type, Haploinsufficient, and E98V Mutant Murine Hematopoietic Progenitor Cells

Project description:This study utilized quantitative mass spectrometry to analyze the proteome and phosphoproteome of Csnk1a1-modified hematopoietic cells. We compared four distinct genotypes: 1. Csnk1a1 WT: Wild-type control. 2. Csnk1a1 fl/+: Heterozygous floxed control (functioning as a pre-recombination baseline). 3. Csnk1a1 -/+: Haploinsufficient model, where endogenous Csnk1a1 was excised through Cre recombination to mimic the dosage loss found in del(5q) MDS. 4. Csnk1a1 E98V: Model expressing the specific E98V point mutation.

2026-09-13 | PXD074599 | Pride

Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics

Project description:This SuperSeries is composed of the following subset Series: GSE30537: Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics [mRNA profiling] GSE30538: Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics [ChIP-seq] Refer to individual Series

2011-10-10 | E-GEOD-30539 | biostudies-arrayexpress

TAB2 haploinsufficiency

Project description:TAB2 haploinsufficiency

| PRJNA747894 | ENA