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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2-AEC)

ABSTRACT: Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2-AEC)

PROVIDER: PRJNA715242 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13995002_1.fastq.gz	Fastqsanger.gz
	SRR13995002_2.fastq.gz	Fastqsanger.gz
	SRR13995003_1.fastq.gz	Fastqsanger.gz
	SRR13995003_2.fastq.gz	Fastqsanger.gz
	SRR13995004_1.fastq.gz	Fastqsanger.gz

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2)

Project description:Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2)

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2-AEC)

Project description:This study investigates the role of regulatory T cell–derived Areg in driving epithelial repair following influenza infection. We use RNA sequencing to probe the gene expression changes within epithelial cells in wildtype mice and in mice that conditionally lack Areg from T cell sources (CD4-cre Areg-flox). Further, we identify a population of damage-associated intermediate alveolar epithelial cells (AECint) that are induced in reponse to acute injury and exhibit gene expression changes reflective of AT2 transdifferentiation to AT1.

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (AT2)

Project description:This study investigates the role of regulatory T cell–derived Areg in driving epithelial repair following influenza infection. We use RNA sequencing to probe the gene expression changes within epithelial cells in wildtype mice and in mice that conditionally lack Areg from T cell sources (CD4-cre Areg-flox). Further, we identify a population of damage-associated transitional alveolar epithelial cells that are induced in reponse to acute injury and exhibit gene expression changes reflective of AT2 transdifferentiation to AT1.

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (10X)

Project description:Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (10X)

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (MesSTIM)

Project description:Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells (MesSTIM)

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Regulation of the alveolar regenerative niche by amphiregulin-producing Treg cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-14 | GSE169127 | GEO

Transcriptome analysis of influenza infected GFP+ AEC compared to bystander GFP- AEC

Project description:A GFP-expressing recombinant A/Puerto Rico/8/1934 influenza virus was used to infect C57BL/6 wild type mice and on day 3 post infection, lung alveolar epithelial cells (AEC) were isolated and sorted based on GFP expression. GFP+ AEC represent the infected AEC and GFP- AEC represent the bystander AEC. AEC were also sorted from uninfected mice to serve as controls.

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Hypercapnia impairs AT2 cell progenitor activity and promotes differentiation to AT1 cells

Project description:Hypercapnia has deleterious effects on cell function, including inhibition of alveolar epithelial cells (AEC) and fibroblast proliferation without causing cell death. Classical studies and lineage-trace models demonstrated that surfactant-producing AT2 cells can serve as stem cells for the structurally and functionally distinct alveolar type 1 cells (AT1) This AT2 reprogramming depends on Wnt/βcat signaling, a pathway that plays critical roles in tissue development and homeostasis throughout the organism lifespan. We found that high CO2 inhibits AT2 cell proliferation and self renewal, and promote their differentiation to ATEC and AT1 cells

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