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RNA-seq analysis CARM1 inhibitor Ellagic acid effect on MDA-MB-231 cells

ABSTRACT: RNA-seq analysis CARM1 inhibitor Ellagic acid effect on MDA-MB-231 cells

PROVIDER: PRJNA720319 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14163133_1.fastq.gz	Fastqsanger.gz
	SRR14163133_2.fastq.gz	Fastqsanger.gz
	SRR14163134_1.fastq.gz	Fastqsanger.gz
	SRR14163134_2.fastq.gz	Fastqsanger.gz
	SRR14163135_1.fastq.gz	Fastqsanger.gz

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lncRNA-seq analysis CARM1 knockdown effect on MDA-MB-231 cells

Project description:Previous studies reported that NEAT1 and its partner p54nrb are necessary for CARM1 to associate with paraspeckles and H3R26 methylation. There are also reports that CARM1 is essential for LincGET's role in guiding the ICM lineage in mouse embryos. We speculate that there may be a connection between CARM1 and lncRNA. In order to verify our guess, we conducted lncRNA-seq experiments against CARM1 control or siRNA in MDA-MB-231 cells to explore the lncRNA that may be regulated downstream of CARM1. Here, we showed that CARM1 and HIF1A co-upregulates the expression of MALAT1 in hypoxia pathway to promote carcinogenesis and metastasis in triple-negative breast cancer cells. These results indicate that there is a connection among CARM1, HIF1A and MALAT1 in triple-negative breast cancer.

2024-03-03 | GSE168121 | GEO

RNA-seq analysis CARM1 inhibitor Ellagic acid effect on MDA-MB-231 cells

Project description:Ellagic acid is a kind of polyphenol lactone, which is widely found in various fruits and nuts. It’s the natural inhibitor of CARM1. Ellagic acid was reported to inhibit breast cancer growth and metastasis. But the mechanism of Ellagic acid has not been investivaged clearly in triple-negative breast cancer (TNBC). Our results indicate that direct inhibition of CDK4 by Ellagic acid limits breast cancer proliferation and metastasis. Our research has determined the molecular basis of Ellagic acid effect in TNBC, which may provide new ideas and drugs for cancer therapy.

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The miRNA profiling in MDA-MB-231, MDA-MB-231/E1A and knockdown of Dicer in MDA-MB-231/E1A cells

Project description:Dicer, RNase III endonuclease, is an essential enzyme in miRNA biogenesis that regulates target gene expression, and it has been reported that aberrant expressions of Dicer associate with the clinical outcomes of patients in various cancers. To explore the miRNA differencial expression regulated by Dicer in MDA-MB-231/E1A cells, the microarray profiling analysis was employed to conduct differentially expressed miRNAs in stable MDA-MB-231/vector, MDA-MB-231/E1A, and MDA-MB-231/E1A/shDicer cells.

2016-01-16 | GSE76924 | GEO

Expression profiles of MDA-MB-231, MDA-231 S1a and S1b

Project description:Identification of genes that are involved in self-seeding by comparing gene expression profiles between parental MDA-MB-231 cells and seeder cells (MDA-231-S1a and S1b) 2 replicates from each sample (parental MDA-MB-231, MDA-MB-231 S1a and MDA-MB-231 S1b) were analyzed

2010-04-07 | E-GEOD-18833 | biostudies-arrayexpress

The miRNA profiling in MDA-MB-231, MDA-MB-231/E1A and knockdown of Dicer in MDA-MB-231/E1A cells

2016-01-16 | E-GEOD-76924 | biostudies-arrayexpress

RNA-seq analysis CARM1 knockdown effect on MDA-MB-231 cells

Project description:RNA-seq analysis CARM1 knockdown effect on MDA-MB-231 cells

| PRJNA704560 | ENA

lncRNA-seq analysis CARM1 knockdown effect on MDA-MB-231 cells

Project description:lncRNA-seq analysis CARM1 knockdown effect on MDA-MB-231 cells

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Genome-wide maps of chromatin state in MDA-MB-231 cells

Project description:In order to figure out the genomic binding landscape of CARM1, we analyzed the genome-wide transcriptional targets for CARM1 using the Chromatin immunoprecipitation based-deep sequencing (ChIP-seq) in MDA-MB-231 cells with antibodies against CARM1. Using Illumina instrument, we found lots of CARM1-specific binding peaks and strong enrichment on the promoters of selected genes involved in classical pathways. This study gave us a new understanding of the role of CARM1 in chromatin status and gene transcription.

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Expression profiles of MDA-MB-231, MDA-231 S1a and S1b

Project description:Identification of genes that are involved in self-seeding by comparing gene expression profiles between parental MDA-MB-231 cells and seeder cells (MDA-231-S1a and S1b)

2010-03-25 | GSE18833 | GEO

MDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis

Project description:The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).

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