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Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

ABSTRACT: Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

PROVIDER: PRJNA723742 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14297316_1.fastq.gz	Fastqsanger.gz
	SRR14297316_2.fastq.gz	Fastqsanger.gz
	SRR14297317_1.fastq.gz	Fastqsanger.gz
	SRR14297317_2.fastq.gz	Fastqsanger.gz
	SRR14297318_1.fastq.gz	Fastqsanger.gz

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Transcriptomic data from lymphocytic choriomeningitis virus-infected and mock-infected A549 cells

Project description:We reported the transcriptomic analysis on A549 cells infected with lymphocytic choriomeningitis virus (LCMV).

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Project description:The experimental data indicate that during a persistent infection, lymphocytic choriomeningitis virus (LCMV) may both directly or indirectly modulate the regulatory cellular processes and alter the cellular functions that are not critical for the survival, but are needed for the homeostasis in the organism. Two-dimensional differential in-gel electrophoresis (2D-DIGE) and MALDI-TOF MS/MS analyses were used to determine the cellular proteome response of HeLa cell line to persistent LCMV infection. Quantitative analysis revealed 24 differentially abundant proteins, half of which were up-regulated and the rest down-regulated. Functional categorization showed that LCMV-responsive proteins were mainly involved in metabolism, stress and defense responses. Among identified proteins, significant changes were found for peroxiredoxins, family of antioxidant enzymes. Decreased amount of these antioxidant proteins was accompanied with the elevation of ROS content in infected cells.

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Project description:Antibody repertoire sequencing of blood and bone marrow plasma cell compartments following lymphocytic choriomeningitis virus infection. Heavy chain repertoires of 5 uninfected mice, 5 acutely infected mice and 5 chronically infected mice were longitudinally sequenced over 80 days. All samples are named according to the following scheme: dpi#_cohort$_R&.fastq.gz . dpi = days post infection = for all samples following the start of infection. Those samples starting with dm10 correspond to blood samples taken before the introduction of any virus. # = time point post virus infection cohort=acute (LCMV), chronic (LCMV), or naive (uninfected) animals $= mouse number, 1-5 R&=paired read, either R1 or R2 Those samples with \"bmpc\" in title correspond to sorted plasma cells (CD138hi, CD19lo) from bone marrow Example: dpi70_chronic3_R2.fastq.gz == blood repertoire 70 days post chronic LCMV infection in chronically-infected mouse#3

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Project description:Effective cancer immunotherapy requires potent tumor antigen-specific effector CD8+ T cell (CTLeff) responses, culminating in an inflammatory activation of the tumor microenvironment. We describe the artificial reengineering of the lymphocytic choriomeningitis virus (LCMV) genome to serve as replication-competent but stably attenuated immunotherapy platform (artLCMV). artLCMV targeted dendritic cells, thereby delivering tumor-associated antigens for efficient CTL induction. Additionally, owing to in vivo spread, artLCMV infected lymphoid tissue stroma expressing interleukin-33, an alarmin released from necrotic cells. Interleukin-33 signals accounted for artLCMV-induced effector CTL responses of higher magnitude and functionality than those induced by replication-deficient LCMV-, adenovirus 5- or vaccinia virus-based vectors. Accordingly, superior immunotherapeutic efficacy of artLCMV in transplantable tumor models depended on interleukin-33 signaling, and massive CTLeff influx was associated with an inflammatory conversion of the tumor. These properties, together with low seroprevalence but excellent immunogenicity of LCMV in humans, suggest artLCMV holds promise as a cancer immunotherapy platform.

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