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Comparative analysis of the effect of different diets on histone H3K4me3 distribution in mouse liver chromatin reveals the epigenetic efficacy of cyanidin-3-O-glucoside dietary intake

ABSTRACT: Comparative analysis of the effect of different diets on histone H3K4me3 distribution in mouse liver chromatin reveals the epigenetic efficacy of cyanidin-3-O-glucoside dietary intake

PROVIDER: PRJNA733655 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14684879.fastq.gz	Fastqsanger.gz
	SRR14684880.fastq.gz	Fastqsanger.gz
	SRR14684881.fastq.gz	Fastqsanger.gz
	SRR14684882.fastq.gz	Fastqsanger.gz
	SRR14684883.fastq.gz	Fastqsanger.gz

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Comparative analysis of the effect of different diets on histone H3K4me3 distribution in mouse liver chromatin reveals the epigenetic efficacy of cyanidin-3-O-glucoside dietary intake

Project description:Background: Different diets result in significantly different phenotypes through metabolic and genomic reprogramming. Epigenetic marks, identified in humans and mouse models upon caloric restriction, high fat diet or the intake of specific bioactives, suggest that genomic reprogramming drives this reprogramming and mediates the effect of nutrition on health. Histone modifications encode the epigenetic signal that adapts genome functions to environmental conditions, including diets, by tuning the structure and properties of chromatin. So far, the effect of different diets on the genome-wide distribution of critical histone marks has not been determined Methods: We investigated by chromatin immunoprecipitation sequencing the distribution of the trimethylation of lysine 4 of histone H3 in the liver of mice fed for one year with five different diets including: chow containing corn powder as extra source of plant bioactives or specifically enriched with the cyanidin-3-O-glucoside, high fat enriched obesogenic and caloric restricted pro-longevity diets Conclusions: The comparison of the resulting histone mark profiles revealed functional food containing cyanidin determines broad effect.

2021-06-30 | GSE175781 | GEO

Comparative Analysis of Histone H3K4me3 Distribution in Mouse Liver in Different Diets Reveals the Epigenetic Efficacy of Cyanidin-3-O-glucoside Dietary Intake.

Project description:Different diets result in significantly different phenotypes through metabolic and genomic reprogramming. Epigenetic marks, identified in humans and mouse models through caloric restriction, a high-fat diet or the intake of specific bioactives, suggest that genomic reprogramming drives this metabolic reprogramming and mediates the effect of nutrition on health. Histone modifications encode the epigenetic signal, which adapts genome functions to environmental conditions, including diets, by tuning the structure and properties of chromatin. To date, the effect of different diets on the genome-wide distribution of critical histone marks has not been determined. Using chromatin immunoprecipitation sequencing, we investigated the distribution of the trimethylation of lysine 4 of histone H3 in the liver of mice fed for one year with five different diets, including: chow containing yellow corn powder as an extra source of plant bioactives or specifically enriched with cyanidin-3-O-Glucoside, high-fat-enriched obesogenic diets, and caloric-restricted pro-longevity diets. Comparison of the resulting histone mark profiles revealed that functional food containing cyanidin determines a broad effect.

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Effects of treatment with cyanidin-3-glucoside on mammary tumors arising from MMTV-PyVT mice

Project description:Cyanidin-3-glucoside (C3G) is one of the most prevalent anthocyanins among dietary polyphenols. Experimental studies suggest that C3G exhibits antioxidant, anti-inflammatory, and cytoprotective effects against various disorders induced by oxidative stress. We examined its in vivo anti-neoplastic properties using MMTV-PyVT transgenic mice, a well-validated model for the development and progression of multistage mammary carcinoma.

2025-03-24 | GSE292678 | GEO

Mechanisms research on Cyanidin-3-O-glucoside ameliorating dextran sulfate sodium (DSS)-induced colitis.

Project description:TMT proteomics for colonic mucosa in DSS-induced colitis mice with or without administrated Cyanidin-3-O-glucoside was used for discovery of differential expressed proteins.

2023-07-10 | PXD043662 |

Quantitative phosphosproteomics revealed the mechanism of Cyanidin-3-O-glucoside ameliorating dextran sulfate sodium (DSS)-induced colitis

Project description:As the exact molecular mechanisms of ulcerative colitis are not fully understood. Cyanidin-3-O-glucoside (C3G) is a compound derived from the food black rice. We investigated whether C3G can ameliorate DSS-induced colitis by using relevant predictions and experiments.

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Understanding the functional role of cyanidin-3-O-glucoside in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis

Project description:Cyanidin-3-O-glucoside (C3G) is one of the most widely distributed anthocyanins and has the effect of reducing the risks of osteoporosis. However, the molecular mechanism by which C3G promotes bone formation remains incompletely understood. Our aim was to investigate the effect of C3G on gene expression profiles, during the proliferation and differentiation in MC3T3-E1, a kind of osteoblast cell line from mice, by RNA sequencing. The results identified 34 up-regulated and 17 down-regulated genes. We further performed Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes analyses (KEGG), and other bioinformatics methods to do further analysis of differentially expressed genes (DEGs). Analysis of sequencing data showed that these genes were highly enriched in functions related to Lysosomal and Glycolipid biosynthetic. Lastly, we used RT-qPCR to validate the differentially expressed mRNAs. The results showed that C3G increased the expression levels of Ly6a (Lymphocyte antigen 6 family member A), Atp6v0c (ATPase H+ transporting v0 subunit c), and decreased the expression levels of Cx3cl1 (C-X3-C motif chemokine ligand 1). This study suggested that C3G activated osteoblast via Glycosylphosphatidylinositol(GPI)-anchor biosynthesis and the Cx3cl1/Cx3cr1 signaling pathway.

2022-10-19 | GSE149731 | GEO

Effects of treatment with cyanidin-3-glucoside on mammary tumors arising from MMTV-PyVT mice

Project description:Effects of treatment with cyanidin-3-glucoside on mammary tumors arising from MMTV-PyVT mice

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Understanding the functional role of cyanidin-3-O-glucoside in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis

Project description:Understanding the functional role of cyanidin-3-O-glucoside in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis

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Transcriptional response to diets varying in phosphor content in pigs (low-intake; medium intake; high-intake)

Project description:in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) due to dietary intake of phosphor

2015-12-30 | GSE66308 | GEO

Transcriptional responsen of phosphorus (re-)absorbing organs to diets varying in phosphorus content in pigs (low-intake; medium intake; high-intake)

Project description:in vivo microarray study of transcriptional changes in porcine jejunum, colon and kidney due to dietary intake of phosphorus

2017-12-31 | GSE94448 | GEO