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Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

ABSTRACT: Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

PROVIDER: PRJNA743028 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15014701_1.fastq.gz	Fastqsanger.gz
	SRR15014701_2.fastq.gz	Fastqsanger.gz
	SRR15014703_1.fastq.gz	Fastqsanger.gz
	SRR15014703_2.fastq.gz	Fastqsanger.gz
	SRR15014705_1.fastq.gz	Fastqsanger.gz

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Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

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Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

Project description:Chronic rhinosinusitis with nasal polyps is a hallmaerk disease in the field of upper airway immunity and chronic inflammation. Diverse inflammatory patterns between nasal polyps have been described in patients that hail from disparate racial and geographic backgrounds. However, it remains unclear whether these immunologic differences in nasal polyps between racial groups are driven by unique molecular mechanisms. We interrogated the gene expression profiles of nasal polyp tissues from Western (United States) and East Asian (Japan) descent, compared to ethmoid sinus tissue controls.

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Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

2021-12-15 | GSE179265 | GEO

In-depth proteomic analysis of nasal secretions from chronic rhinosinusitis and nasal polyps

Project description:Considering the complex and multifarious features of Chronic rhinosinusitis (CRS) including immunologic patterns, novel modalities are needed to reflect clinical and pathophysiological endotypes beyond nasal polyps.We aimed to investigate the proteome of nasal secretions on filter paper from CRS patients to characterize endotypes.

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Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-15 | GSE179269 | GEO

Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Low Input

Project description:This study used nasal transcriptomic profiling of the inferior turbinate in control and pediatric ARDS subjects to identify endotypes. This data set is for amplified specimens. The study identfied three pediatric ARDS endotypes.

2020-06-23 | GSE152979 | GEO

Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Standard Input

Project description:This study used nasal transcriptomic profiling of the inferior turbinate in control and pediatric ARDS subjects to identify endotypes. This data set is for non-amplified specimens. The study identfied three pediatric ARDS endotypes.

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A global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps

Project description:Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulation of APA site switching. The objective of this study was to explore the profiling of tandem APA sites in nasal polyps compared with nasal uncinate process mucosa. Methods: Sequencing of APA sites (SAPAS) based on second-generation sequencing technology was undertaken to investigate the use of tandem APA sites and identify gene expression patterns in samples from the nasal polyps and nasal uncinate process mucosa of two patients with chronic rhinosinusitis with nasal polyps. The findings of the SAPAS analysis were validated via quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Results: First, the results showed a switching of 3'UTR lengths in nasal polyps compared with nasal uncinate process mucosa. From the two patients, 105 overlapping genes in the nasal polyps were switched to distal poly(A) sites, and 90 such genes were switched to proximal poly(A) sites. Several Gene Ontology terms were enriched in the list of genes with switched APA sites, including transcription regulation, cell cycle, apoptosis, and metabolism. Second, we detected genes that showed differential expression with at least a 3-fold difference between nasal polyp tissue and nasal uncinate process mucosa. Between the two sample types, 627 genes exhibited differential expression. The qRT-PCR results confirmed our SAPAS results. Conclusion: APA site-switching events of 3'UTRs are prevalent in nasal polyp tissue, and the regulation of gene expression mediated by APA may play an important role in the formation and persistence of nasal polyps. Our results may provide new insights into the possible pathophysiologic processes involved in nasal polyps.

2012-12-31 | GSE39957 | GEO

Proteomic analysis of mucus from chronic rhinosinusitis patients with or without nasal polyps

Project description:Patients with chronic rhinosinusitis (CRS) have abnormal immune responses triggered by a variety of infectious agents, airborne toxins and fungi. Respiratory epithelial cells serve as relay stations capable of amplifying or augmenting cues received from external stimuli to nearby immune cells located in the sinus mucosa. Previous studies have identified increases in complement components and complement gene expression in the mucosa of patients with atopic CRS with nasal polyps (CRSwNP). As part of a larger study, we used shotgun proteomics to quantify changes in mucus proteins between patients with and without nasal polyps.

2016-05-26 | PXD004144 | Pride

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