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Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RNA-seq]

ABSTRACT: Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RNA-seq]

PROVIDER: PRJNA745565 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15100896_1.fastq.gz	Fastqsanger.gz
	SRR15100896_2.fastq.gz	Fastqsanger.gz
	SRR15100897_1.fastq.gz	Fastqsanger.gz
	SRR15100897_2.fastq.gz	Fastqsanger.gz
	SRR15100898_1.fastq.gz	Fastqsanger.gz

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Genes differentially methylated after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RRBS]

Project description:reduced representation bisulfite sequencing (RRBS) sequencing was performed to analyze methylation profiles regulated by DNMT1 in C3H10T1/2 MSCs with or without OB differentiation.

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Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RNA-seq]

Project description:RNA sequencing was performed to analyze potential genes regulated by DNMT1 in C3H10T1/2 MSCs with or without OB differentiation.

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Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation

Project description:Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation

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Genes differentially methylated after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RRBS]

Project description:Genes differentially methylated after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RRBS]

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Genes differentially expressed during early osteoblast (OB) differentiation

Project description:Genes differentially expressed during early osteoblast (OB) differentiation

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Genes differentially expressed after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Project description:The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment leads to alterations to the epigenome. Using mass spectrometry and complementary alanine mutation experiments, we identified S878 as the major residue that is O-GlcNAcylated on DNMT1. Functional studies further revealed that O-GlcNAcylation of DNMT1-S878 results in an inhibition of methyltransferase activity, resulting in a general loss of DNA methylation that is preferentially at partially methylated domains (PMDs). This loss of methylation corresponds with an increase in DNA damage and apoptosis. These results establish O-GlcNAcylation of DNMT1 as a mechanism through which the epigenome is regulated by glucose metabolism and implicates a role for glycosylation of DNMT1 in metabolic diseases characterized by hyperglycemia.

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Genes differentially expressed during early osteoblast (OB) differentiation

Project description:RNA-seq analysis was performed to identify early OB-regulating genes in C3H10T1/2 MSCs.

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Gene expression in the GWAT of ob/ob and ob/ob/Fsp27-/- mice

Project description:GWAT store most of the TAG in mice, ob/ob mice is an obese mice. Ob/ob/Fsp27-/- mice are lean when compared with ob/ob mice. The GWAT weight was dramatically reduced in ob/ob/Fsp27-/- mice. We next extract the total RNA from the GWAT of ob/ob and ob/ob/Fsp27-/- mice, to perform microaary analysis using Mouse Genome 430 2.0 arrays, Affymetrix. We then analysised the up-regulated and down regulated pathways.

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Gene Expression in the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice

Project description:ob/ob mice is an obese mice. CIDE family proteins including Cidea, Cideb and Cidec play important role in lipid metabolism. Cidea is mainly expressed in the brown adipose tissue (BAT). Cidec is mainly expressed in the BAT and white adipose tissue (WAT). We generated ob/ob/Cidea-/-/Cidec-/- mice to investigate the phenotype of fat tissue. ob/ob/Cidea-/-/Cidec-/- mice are lean when compared with ob/ob mice. The tissue weight and TAG content of BAT and WAT was extreamly decreased in ob/ob/Cidea-/-/Cidec-/- mice compared with that in ob/ob mice. We next extract the total RNA from the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice, to perform microarray analysis using Mouse Gene 1.0 ST array system, Affymetrix. We then analysised the up-regulated and down regulated pathways.

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