Project description:Differential genes in adipocytes induced from polycystic ovary syndrome-derived and non- polycystic ovary syndrome-derived human embryonic stem cells
Project description:To explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS)
Project description:Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.
Project description:Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.
