Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ionizing Radiation-induced Acute Damage in the Salivary Gland

ABSTRACT: Ionizing Radiation-induced Acute Damage in the Salivary Gland

PROVIDER: PRJNA765603 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16024094_1.fastq.gz	Fastqsanger.gz
	SRR16024094_2.fastq.gz	Fastqsanger.gz
	SRR16024095_1.fastq.gz	Fastqsanger.gz
	SRR16024095_2.fastq.gz	Fastqsanger.gz
	SRR16024096_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Ionizing Radiation-induced Acute Damage in the Salivary Gland

Project description:Ionizing radiation (IR) – induced salivary gland damage is a common adverse effect in radiotherapy for patients with head and neck cancers. Currently, there is no effective treatment for the resulting salivary gland hypofunction and xerostomia (dry mouth). Here we profiled the acute gene expression change in the mouse submandibular salivary gland, and defined its damage response patterns at the transcriptome level.

2021-09-23 | GSE184673 | GEO

Ionizing Radiation-induced Acute Damage in the Submandibular Gland

Project description:Ionizing Radiation-induced Acute Damage in the Submandibular Gland

| PRJNA880554 | ENA

Ionizing radiation induced hair and skin damage

Project description:Ionizing radiation induced hair and skin damage

| PRJNA687009 | ENA

Ionizing Radiation-induced Acute Damage in the Submandibular Gland

Project description:To investigate the unique mechanism of radiation submandibular gland injury, we gave 15Gy local one-time irradiation to the submandibular gland area of eight-week-old C57BL/6J female mice. We then collected submandibular glands 24 hours after radiation for transcriptome sequencing.

2026-09-01 | GSE213334 | GEO

Integrating metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction

Project description:Purpose: The goal of this study is to integrate NGS-derived parotid salivary gland transcriptome profiling (RNA-seq) to metabolomics (UPLC-MS/MS) methods and identify mechanisms driving radiation-induced xerostomia, with potential clinical application to head and neck cancer patients. Methods: Parotid salvary gland mRNA profiles of 28-day-old wild-type (WT) and 5 Gy radiation treated mice were generated by deep sequencing, in triplicate, using Illumina TruSeq. The sequenced reads that passed quality filters were trimmed with Trimmomatic, mapped to mm10 genome with HISAT2, and summarized at the gene level with HTSeq-count and analyzed with DESeq2. Results: Using an optimized data analysis workflow, we mapped sequenced reads per sample to the mouse genome (build mm10) and identified 25422 genes with at least 1 read in the parotid glands of WT and radiation treated mice with HISTA2 workflow. RNA-seq data QA/QC by Principal Component Analysis showed a clear separation between conditions. 155 genes showed significant differential expression between the WT and radiation treated salivary gland, with an adjsuted p-value < 0.05. Pre ranked Gene Set Enrichment Analysis against the CPDB database led to 859 altered pathways with a p-value < 0.05. Integrative analysis pointed to 103 RNA-Seq/Metabolite joint enriched pathways with a p-value < 0.05.

2021-03-31 | GSE155902 | GEO

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

Project description:Tardigrades can survive remarkable doses of ionizing radiation, up to about 1000 times the lethal dose for humans. How they do so is incompletely understood. We found that the tardigrade Hypsibius exemplaris suffers DNA damage upon gamma irradiation, but damage is repaired. We show that tardigrades have a specific and robust response to ionizing radiation: irradiation induces a rapid, dramatic upregulation of many DNA repair genes. By expressing tardigrade genes in bacteria, we validate that increased expression of some repair genes can suffice to increase radiation tolerance. We show that at least one such gene is necessary for tardigrade radiation tolerance. Tardigrades’ ability to sense ionizing radiation and massively upregulate specific DNA repair pathway genes may represent an evolved solution for maintaining DNA integrity.

2024-12-13 | PXD047724 | Pride

Generation of functional salivary gland progenitor cells from extended pluripotent stem cells

Project description:The aim of this study was to use pluripotent stem cells (PSCs) as a starting point to progressively differentiate into induced salivary gland progenitor cells (iSGPCs) by mimicking salivary gland development. In this study, we further explored and optimized the passage strategy and organoid formation protocol of iSGPCs based on our previous studies. After 17 days of differentiation, PSC-derived iSGPCs exhibited a marker expression profile similar to that of adult salivary gland progenitors, including KRT5, KRT14, KRT19, and CD49F. Functionally, iSGPCs exhibit self-renewal capacity, are able to form salivary gland-like branching organoids, and have therapeutic potential in models of radiation-induced salivary gland hypofunction.

2026-03-27 | GSE293153 | GEO

Single cell sequencing analysis of control, photon- and proton- irradiated salivary gland organoids at day 7 and control salivary gland organoids at day 11

Project description:The specific impact of different radiation types, such as photons and protons, and their effects on normal stem cell activity and tissue regeneration are unknown. In this study, we used a scRNA-seq approach to characterize our mouse salivary gland organoid model at day 7 and 11 and assess the effects of photon and proton irradiation on salivary gland stem/progenitor cells at day 7.

2025-09-23 | GSE272759 | GEO

Possible DNA damage after paternal exposure to ionizing radiation in radar technicians

Project description:Effects of accidental and prolonged radiation exposure on the human germline remain a topic of medical interest. Transgenerational signatures of ionizing radiation exposure are primarily implicated to be clustered de-novo mutations (cDNMs, multiple de-novo mutations within 20bp). We sequenced the whole genome of 110 children from 70 families (Radar cohort). The father in this cohort were exposed to 0-353mSv of ionizing radiation and serve as exposed samples.

| EGAS00001007321 | EGA

Epigenetic regulation of gene expression in mouse skin after ionizing radiation damage

Project description:Back skin from 8-10 weeks male mice was plucked to induce actively growing hair follicles. After 9 days, the back skin was irradiated with 5Gy ionizing radiation. Skin samples were collected for CHIP-seq analysis using a p53 antibody and H3K4me3 antibody. We compared wild type and Krt17 knock out mice for their epigenetic regulation of gene expression change in response to ionizing radiation

2021-01-31 | GSE165840 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data