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An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

ABSTRACT: An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

PROVIDER: PRJNA790625 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17272600_1.fastq.gz	Fastqsanger.gz
	SRR17272600_2.fastq.gz	Fastqsanger.gz
	SRR17272599_1.fastq.gz	Fastqsanger.gz
	SRR17272599_2.fastq.gz	Fastqsanger.gz

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An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

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An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

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MicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7

Project description:We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miRNAs were up-regulated with aneurysm and 37 down-regulated at p<0.05, which were also altered by >1.5-fold. Utilizing the PPE infusion model, we induced AAA in Male 10-week-old C57/Bl6 mice, 7 days after AAA-induction with PPE. One array per mouse, 5 mice per group, two groups (PPE and sham).

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Gene expression data from aortic tissues of PPE-AAA mice receiving systemic lenvatinib treatment

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