Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA methylation profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs control mice

ABSTRACT: DNA methylation profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs control mice

PROVIDER: PRJNA793132 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

lncRNA profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs Th2-mediated eosinophil-predominant asthma mice and control mice

Project description:Recently, epigenetic regulation was shown to play an important role in asthma development. In particular, lncRNA, as one of the important epigenetic modifications, has been proved to be related to the pathogenesis of asthma. However, little is known about the lncRNA expression in Th17-mediated neutrophil-predominant asthma. To investigate the potential functions of lncRNA that affect the pathogenesis of Th17-mediated neutrophil-predominant asthma, a Agilent Mouse lncRNA （4*180K，Design ID：049801）Array was used to detect the lncRNA and mRNA profiles of lungs from Th17-mediated neutrophil-predominant asthma mice.

2024-12-30 | GSE192904 | GEO

DNA methylation profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs control mice

Project description:Recently, epigenetic regulation was shown to play an important role in asthma development. In particular, DNA methylation, as one of the important epigenetic modifications, has been proved to be related to the pathogenesis of asthma. However, little is known about the DNA methylation status in Th17-mediated neutrophil-predominant asthma. To investigate the potential functions of DNA methylation that affect the pathogenesis of Th17-mediated neutrophil-predominant asthma, a methylated DNA immunoprecipitation (MeDIP) chip was used to detect the whole genome single-base DNA methylation profiles of lungs from Th17-mediated neutrophil-predominant asthma mice.

2024-12-29 | GSE192781 | GEO

lncRNA profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs Th2-mediated eosinophil-predominant asthma mice and control mice

Project description:lncRNA profiling in lungs of Th17-mediated neutrophil-predominant asthma mice vs Th2-mediated eosinophil-predominant asthma mice and control mice

| PRJNA793705 | ENA

CIP2A negatively regulates Th17 differentiation

Project description:Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) regulates IL-17 production by Th17 cells in human and mouse. Using CIP2A knock-out (KO) mice and siRNA-mediated CIP2A silencing in human primary CD4+ T cells, we demonstrated that CIP2A silencing results in a significant increase in IL-17 production. Interestingly, CIP2A deficient Th17 cells were characterized by increased strength and duration of STAT3 (Y705) phosphorylation. Genome-wide gene expression profile as well as the p-STAT3 (Y705) interactome of CIP2A deficient Th17 cells identified that CIP2A regulates the strength of the interaction between Acylglycerol kinase (AGK) and STAT3, and thereby, modulates STAT3 phosphorylation as well as expression of IL-17 in Th17 cells. Our results uncover the physiological function of CIP2A in Th17 cells and provides new opportunities for therapeutic intervention in Th17 cell mediated diseases.

2020-05-26 | PXD010612 | Pride

Gene expression analysis of WT Th17 versus STAT4 deficient Th17 cells from EAE mice

Project description:The purpose of this study is to compare transcriptional profiles of WT and STAT4-deficient Th17 cultured cells from mice with experimental autoimmune encephalomyelitis (EAE) using RNA sequencing. WT and STAT4 deficient splenocytes from EAE immunized mice were cultured with MOG peptide under Th17 conditions for three days, and then total RNA was extracted from CD4 T cells for sequencing. Differential gene expression was determined using the DESeq2 algorithm. These data reveal a previously unrecognized role for STAT4 in Th17 gene expression and function.

2023-03-30 | GSE227049 | GEO

Lungs from bleomycin-treated 129svJ mice

Project description:Profile of gene expression of lungs from bleomycin-treated C129svJ mice.

2010-06-05 | E-GEOD-452 | biostudies-arrayexpress

Lungs from bleomycin-treated 129svJ mice

Project description:Profile of gene expression of lungs from bleomycin-treated C129svJ mice. Keywords: parallel sample

2003-06-11 | GSE452 | GEO

Gene expression analysis of WT Th17 versus STAT4 deficient Th17 cells from EAE mice

Project description:Gene expression analysis of WT Th17 versus STAT4 deficient Th17 cells from EAE mice

| PRJNA942960 | ENA

Human Th17 Cell differentiation

Project description:The early stages of human Th17 Cell differentiation were studied using label free proteomics to compare Th17 polarized CD4+ human T cells at 24 h and 72 h with activated cells (72 and 24 h) and Thp cells.

2019-01-28 | PXD008973 | Pride

Lungs from bleomycin-treated A/J mice

Project description:Profile of gene expression of lungs from bleomycin-treated A/J mice.

2010-06-05 | E-GEOD-451 | biostudies-arrayexpress