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Next Generation Sequencing Analysis on Grafts with Macrosteatosis for Liver Transplantation in rats

ABSTRACT: Next Generation Sequencing Analysis on Grafts with Macrosteatosis for Liver Transplantation in rats

PROVIDER: PRJNA797664 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17631608_1.fastq.gz	Fastqsanger.gz
	SRR17631608_2.fastq.gz	Fastqsanger.gz
	SRR17631609_1.fastq.gz	Fastqsanger.gz
	SRR17631609_2.fastq.gz	Fastqsanger.gz
	SRR17631610_1.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing Analysis on Grafts with Macrosteatosis for Liver Transplantation in rats

Project description:We reported the transcriptomic expression profile of the MaS/non-MaS graft samples from rats before/after liver transplantation and long-term surviving rats.

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Unique early gene expression patterns in adult to adult living donor liver grafts compared to deceased donor grafts

Project description:Because of inherent differences between deceased donor (DD) and living donor (LD) liver grafts, we hypothesize that the molecular signatures will be unique, correlating with specific biologic pathways and clinical patterns. Following reperfusion, 579 genes in DD grafts and 1324 genes in LDs were differentially expressed (p<0.005). Many up-regulated LD genes were related to regeneration, biosynthesis and cell cycle, and a large number of down-regulated genes were linked to hepatic metabolism and energy pathways correlating with post-transplant clinical laboratory findings. There was significant up-regulation of inflammatory/immune genes in both DD and LD, each with a distinct pattern. Gene expression patterns of select genes associated with inflammation and regeneration in LD and DD grafts correlated with protein expression. Unique patterns of early gene expression are seen in LD and DD liver grafts, correlating with protein expression and clinical results, demonstrating distinct inflammatory profiles and significant down-regulation of metabolic pathways in LD grafts. Keywords: liver transplantation, live donor transplantation, liver regeneration, microarrays, mRNA expression, reperfusion injury

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