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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

ABSTRACT: Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

PROVIDER: PRJNA802532 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17844076_1.fastq.gz	Fastqsanger.gz
	SRR17844076_2.fastq.gz	Fastqsanger.gz
	SRR17844077_1.fastq.gz	Fastqsanger.gz
	SRR17844077_2.fastq.gz	Fastqsanger.gz
	SRR17844078_1.fastq.gz	Fastqsanger.gz

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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage

Project description:Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage

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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (scRNA-Seq)

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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (Bulk RNA-Seq)

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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

Project description:We reported the allele-specific single cell RNA sequencing in highly morphogenic (C57Bl6J-maternal x CASTEiJ-paternal) male F1 mouse embryonic stem cells (mESC) and in vitro mESC derived six cardiac lineage cell types. We demonstrated distinctive gene regulation based on the parental origin of the alleles. We showed that deterministic and stochastic monoalleleic gene classes are distinctive in regulation and are involved in unique processes. In this study we highlighted the importance of parental origin-specific gene expression in development, homeostasis and disease.

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scNanoSeq-CUT&Tag: a long-read single-cell CUT&Tag sequencing method for efficient chromatin modification profiling within individual cells

Project description:We developed scNanoSeq-CUT&Tag, a streamlined method by adapting a modified CUT&Tag protocol to Oxford Nanopore sequencing platform for efficient chromatin modification profiling at single-cell resolution. We firstly tested the performance of scNanoSeq-CUT&Tag on six human cell lines: K562, 293T, GM12878, HG002, H9, HFF1 and adult mouse blood cells, it showed that scNanoSeq-CUT&Tag can accurately distinguish different cell types in vitro and in vivo. Moreover, scNanoSeq-CUT&Tag enables to effectively map the allele-specific epigenomic modifications in the human genome andallows to analyze co-occupancy of histone modifications. Taking advantage of long-read sequencing,scNanoSeq-CUT&Tag can sensitively detect epigenomic state of repetitive elements. In addition, by applying scNanoSeq-CUT&Tag to testicular cells of adult mouse B6D2F1, we demonstrated that scNanoSeq-CUT&Tag maps dynamic epigenetic state changes during mouse spermatogenesis. Finally, we exploited the epigenetic changes of human leukemia cell line K562 during DNA demethylation, it showed that NanoSeq-CUT&Tag can capture H3K27ac signals changes along DNA demethylation. Overall, we prove that scNanoSeq-CUT&Tag is a valuable tool for efficiently probing chromatin state changes within individual cells.

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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (scRNA-Seq)

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