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Retinoic Acid Receptor Gamma is Required for Proliferation of Pancreatic cancer cells

ABSTRACT: Retinoic Acid Receptor Gamma is Required for Proliferation of Pancreatic cancer cells

PROVIDER: PRJNA810709 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18150726_1.fastq.gz	Fastqsanger.gz
	SRR18150726_2.fastq.gz	Fastqsanger.gz
	SRR18150727_1.fastq.gz	Fastqsanger.gz
	SRR18150727_2.fastq.gz	Fastqsanger.gz
	SRR18150728_1.fastq.gz	Fastqsanger.gz

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Retinoic Acid Receptor Gamma is Required for Proliferation of Pancreatic cancer cells

Project description:Despite of the expectation that retinoic acid receptor could be the potential therapeutic targets for pancreatic cancers, there has been the lack of information about the role and the impact of Retinoic acid receptor gamma (RARγ, RARG) on pancreatic cancer, unlike other two RARs.RARG is commonly over-expressed in human pancreatic cancer and is an independent diagnostic marker predicting the poor prognosis of pancreatic cancer patients. In addition, we demonstrated that the reduction in the expression of RARG in human pancreatic cancer cells dramatically suppress their proliferation and tumor growth in vivo, partially attributable to the down-regulation of tumor-supporting biological processes such as glucose transport and the decreased expression of various oncogenes like MYC and STAT3.

2022-07-01 | GSE197499 | GEO

Transcription profiling of F9 teratocarcinoma sublines characterized by the presence or absence of the RAR gamma nuclear retinoic acid receptor treated with trans retinoic acid and the novel retinoid, ST1926

Project description:Effect of all trans retinoic acid and the novel retinoid, ST1926, on the profile of gene expression in F9 teratocarcinoma sublines characterized by the presence or absence of the RAR gamma nuclear retinoic acid receptor

2005-12-31 | E-MEXP-361 | biostudies-arrayexpress

Inhibition of Retinoic Acid Receptor Gamma Improves Bovine Embryo Development

Project description:Inhibition of Retinoic Acid Receptor Gamma Improves Bovine Embryo Development

| PRJNA1304398 | ENA

Inhibition of Retinoic Acid Receptor Gamma Improves Bovine Embryo Development

Project description:Retinoic acid receptor gamma (RARγ) plays a critical but poorly understood role in early embryo development and stem cell pluripotency. Here, we investigated the effects of the RARγ-specific inhibitor LY2955303 (LY) on in vitro-produced bovine embryos. Treatment with LY significantly increased blastocyst rates and quality, demonstrating its potential to enhance IVF outcomes in cattle. Single-embryo RNA sequencing using Smart-seq indicated that LY promotes metabolic reprogramming (upregulating glycolysis and TCA cycle activity) while suppressing apoptosis and inflammatory responses. LY- treatment starting from 16-cell stage led to enhanced glycolysis in blastocysts compared with exposure from 2-cell stage. Furthermore, LY-treatment also upregulated oxidative phosphorylation in bovine embryonic stem cells (ESCs). These findings establish RARγ as an important regulator of bovine embryo development, with its inhibition offering a novel strategy to optimize IVF embryo culture systems for livestock production.

2025-12-03 | GSE305071 | GEO

TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells

Project description:DNA topoisomerase II beta (TOP2B), is required for correct execution of certain developmental transcriptional programs and for signal-induced transcriptional activation, including transcriptional activation by nuclear hormone ligands such as retinoic acid. In addition, TOP2B is enriched at genomic locations occupied by CTCF and cohesin (RAD21) suggesting a role in chromosome looping and/or establishing or maintaining aspects of chromosome 3D structure. This led us to investigate the effect of TOP2B inactivation on patterns of intra- and inter- chromosomal interaction that reflect the higher-level 3D architecture of the genome. Using the retinoic acid responsive SH-SY5Y neuroblastoma cell line model, we had previously demonstrated a large number of gene expression changes upon retinoic acid treatment and upon depletion of TOP2B. However, we report here that these expression changes are accompanied by only subtle changes in chromosome organization. While there was no evidence for changes in cohesin loops or topologically associating domains, lack of TOP2B did affect compartment strength changes that occur upon ATRA treatment.

2025-03-27 | GSE252149 | GEO

Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration

Project description:Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration

| PRJNA1138466 | ENA

Expression data from retinoic acid induced newborn rat epidermal keratinocytes

Project description:Epidermal keratinization is a tightly regulated process essential for skin barrier function, requiring coordinated control of keratinocyte proliferation and differentiation. Retinoic acid, a bioactive metabolite of vitamin A, is known to promote keratinocyte proliferation while suppressing differentiation; however, the molecular mechanisms underlying this dual regulation remain incompletely understood. We analyzed retinoic acid-induced changes in proliferative characteristics and keratinization-associated differentiation, assessed global gene expression profiles. (Microarray)

2026-03-13 | GSE319564 | GEO

Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human pancreatic islet cell specification

Project description:Retinoic acid (RA) signaling is essential for multiple developmental processes, including appropriate pancreas formation from the foregut endoderm. RA is also required to generate pancreatic progenitors from human pluripotent stem cells. However, the role of RA during the later stages of pancreas development is not well understood. In this study, we generated an inducible system to block RA signaling and demonstrate that disruption of the RA pathway within the Neurog3-expressing endocrine progenitor population is required for appropriate mouse b cell differentiation and repression of critical d cell genes, including Somatostatin. In addition, inhibition of the RA pathway in hESC-derived pancreatic progenitors downstream of NEUROG3 induction impairs INSULIN expression. We further determined that RA-regulation of endocrine cell differentiation is mediated through Wnt pathway components. Together, these data demonstrate the importance of RA signaling in endocrine specification and identify conserved mechanisms by which RA signaling directs endocrine cell fate.

2020-06-02 | GSE144953 | GEO

The influence of retinoic acid on immortalized human meibomian gland epithelial cells

Project description:HumanHT-12v4 microarray of cells in proliferation and differentiation conditions treated with or without 2 uM retinoic acid Cells were treated with or without 2 uM retinoic acid, in proliferation (KSFM + 5 ng/ml EGF + 50 ug/ml bovine pituitary extract) and differentiation (DMEM/F12 + 10 ng/ml EGF + 10% FBS) media

2012-05-18 | E-GEOD-37089 | biostudies-arrayexpress

Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells

Project description:All-trans retinoic acid (ATRA) alters gene expression in CCE WT embryonic stem cells, but has no effect on gene expression in RAR-deficient TKO cells (devoid of Retinoic Acid Receptors α, β, and γ)

2018-05-25 | GSE112412 | GEO

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