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Gene expression in macrophages from mice fed in Western diet

ABSTRACT: Gene expression in macrophages from mice fed in Western diet

PROVIDER: PRJNA851058 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19754175_1.fastq.gz	Fastqsanger.gz
	SRR19754175_2.fastq.gz	Fastqsanger.gz
	SRR19754176_1.fastq.gz	Fastqsanger.gz
	SRR19754176_2.fastq.gz	Fastqsanger.gz
	SRR19754177_1.fastq.gz	Fastqsanger.gz

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Renal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet

Project description:Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), PTC-LRP2 +/+ and -/- littermates in an LDL receptor -/- background were generated and fed a Western diet to determine effects of PTC-derived megalin on atherosclerosis. PTC-specific megalin deletion did not attenuate atherosclerosis in LDL receptor -/- mice in either sex. Serendipitously, we discovered that PTC-specific megalin deletion led to interstitial infiltration of CD68+ cells and tubular atrophy. The pathology was only evident in male PTC-LRP2 -/- mice fed the Western diet, but not in mice fed a normal laboratory diet. Renal pathologies were also observed in male PTC-LRP2 -/- mice in an LDL receptor +/+ background fed the same Western diet, demonstrating that the renal pathologies were dependent on diet and not hypercholesterolemia. By contrast, female PTC-LRP2 -/- mice had no apparent renal pathologies. In vivo multiphoton microscopy demonstrated that PTC-specific megalin deletion dramatically diminished albumin accumulation in PTCs within 10 days of Western diet feeding. RNA sequencing analyses demonstrated the upregulation of inflammation-related pathways in kidney. Overall, PTC-specific megalin deletion leads to tubulointerstitial nephritis in mice fed Western diet, with severe pathologies in male mice.

2024-07-04 | GSE268879 | GEO

Effect of beta3-adrenergic stimulation on liver gene expression in mice fed either a control diet or a western diet

Project description:The effect of beta3-adrenegic stimulation on liver gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. Beta 3 adrenergic stimulation was achieved by using Beta 3 adrenergic receptor (CL316243). Overall, this experiment allowed us to investigate the effect of Beta3-adrenergic stimulation on liver gene expression in healthy mice and in obese mice.

2025-09-03 | GSE279895 | GEO

Changes in hepatic transcriptome profile in α4β7 mAb-treated Western diet-fed mice

Project description:Hepatic transcriptome of junctional adhesion molecule A knockout, F11r–/– mice fed a Western diet (WD) for eight weeks. A cohort of WD-fed mice were treated with IgG or α4β7 mAb for four weeks starting at week four following initiation of the WD.

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Effect of beta3-adrenergic stimulation on brown adipose tissue gene expression in mice fed either a control diet or a western diet

Project description:The effect of beta3-adrenegic stimulation on brown adipose tissue gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. Beta 3 adrenergic stimulation was achieved by using Beta 3 adrenergic receptor (CL316243). Overall, this experiment allowed us to investigate the effect of Beta3-adrenergic stimulation on brown adipose tissue gene expression in healthy mice and in obese mice.

2025-09-03 | GSE279897 | GEO

Effect of thermoneutral housing (as compared to room temparture) on liver gene expression in mice fed a control diet or a western diet

Project description:Liver gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. In each diet, half of the mice were housed at room temperature (22°C) and the other half was housed at thermoneutrality (30°C). Overall, this experiment allowed us to investigate the effect of housing temperature on liver gene expression in healthy mice and in obese mice.

2025-09-03 | GSE280075 | GEO

Renal Proximal Tubule Cell-Specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed a Western Diet

Project description:Female Lrp2 (megalin) f/f mice were bred with male Ndrg1-Cre ERT2 +/0 mice to develop PTC-LRP2 +/+ and PTC-LRP2-/- littermates. To study atherosclerosis, all mice were bred to an LDL receptor -/- background and fed a Western diet to induce atherosclerosis. PTC-specific megalin deletion did not attenuate atherosclerosis in LDL receptor -/- mice in either sex. Serendipitously, we discovered that PTC-specific megalin deletion led to interstitial infiltration of CD68+ cells and tubular atrophy. The pathology was only evident in male PTC-LRP2 -/- mice fed the Western diet, but not in mice fed a normal laboratory diet. Renal pathologies were also observed in male PTC-LRP2 -/- mice in an LDL receptor +/+ background fed the same Western diet, demonstrating that the renal pathologies were dependent on diet and not hypercholesterolemia. In contrast, female PTC-LRP2 -/- mice had no apparent renal pathologies. Urine proteomics analysis discovered that many megalin ligands were increased in urine of male PTC-LRP2 -/- mice, compared to their PTC-LRP2 +/+ littermates.

2025-10-24 | PXD066759 | Pride

Effect of plasma from western diet fed mice on bone marrow derived macrophages (BMDM)

Project description:Effect of plasma from western diet fed mice on bone marrow derived macrophages (BMDM)

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The effects of myeloid-specific Lipa overexpression on the transcriptomic profile of aortic plaque macrophages in mice on the Ldlr-/- background and fed a Western diet for 16 weeks

Project description:We analyzed the transcriptomic profile of aortic macrophages directly sorted from atherosclerotic aortas of two groups of mice fed a Western diet for 16 weeks: (1) mice with LysMCre-mediated myeliod-specific Lipa overexpression on the Ldlr-/- background; (2) LysMCre-negative littermates on the Ldlr-/- background.

2025-08-01 | GSE285961 | GEO

Effect of depletion of TAS1R3 on testicular gene expression in mice fed long-term western diet

Project description:Recent studies suggest that the western diet negatively affects male reproduction, but few underlying molecular mechanisms have been established. Also, several studies have reported TAS1R3 is expressed in testis, epididymis and sperm, but their role in male reproduction remains unknown. To investigate the function of taste receptor TAS1R3 in the male reproductive function under western diet condition, we performed RNA-sequencing analysis on testes from C57BL/6 mice fed long-term (18 weeks) western diet.

2024-12-19 | GSE221433 | GEO

Hepatic gene expression in wild type and SHPKO mice fed chow or western diet

Project description:SHP (small heterodimer partner; NR0B2) belongs to the nuclear hormone receptor superfamily, which regulates numerous developmental and metabolic cellular functions. To study physiological function of SHP, we generated congenic SHP-/- mice on C57Bl/6 background. When the congenic SHP-/- mice were challenged with a western diet (harlan, TD.88137) for 22 weeks, they were resistant to diet induced obesity and hepatic steatosis compared to WT controls. However, their hepatic insulin sensitivity was compromised when assessed with phospho-Akt levels after insulin injection. Therefore, we investigated hepatic gene expression using illumina beadchip array to explore mechanisms underneath the unique liver physiology in SHP-/- mice. Livers were collected from C57Bl/6 wild type and C57Bl/6 SHP-/- mice fed chow or western diet. The 1 microgram of total RNA obtained from individual mouse (n=4 per group) and subjected to illumina beadchip gene expression profiling.

2012-05-16 | E-GEOD-38013 | biostudies-arrayexpress

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