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ABSTRACT: Study on microbial diversity of rat intestinal contents

PROVIDER: PRJNA911986 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22728140_1.fastq.gz	Fastqsanger.gz
	SRR22728140_2.fastq.gz	Fastqsanger.gz
	SRR22728141_1.fastq.gz	Fastqsanger.gz
	SRR22728141_2.fastq.gz	Fastqsanger.gz
	SRR22728142_1.fastq.gz	Fastqsanger.gz

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Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Project description:Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate. culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small-intestinal microbial diversity and small-intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.

2019-03-14 | GSE128189 | GEO

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