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A novel Modulator of Ring Stage Translation (MRST) gene alters artemisinin sensitivity in Plasmodium falciparum

ABSTRACT: A novel Modulator of Ring Stage Translation (MRST) gene alters artemisinin sensitivity in Plasmodium falciparum

PROVIDER: PRJNA926593 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23193300_1.fastq.gz	Fastqsanger.gz
	SRR23193300_2.fastq.gz	Fastqsanger.gz
	SRR23193301_1.fastq.gz	Fastqsanger.gz
	SRR23193301_2.fastq.gz	Fastqsanger.gz
	SRR23193302_1.fastq.gz	Fastqsanger.gz

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A novel Modulator of Ring Stage Translation (MRST) gene alters artemisinin sensitivity in Plasmodium falciparum

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Project description:Artemisinin resistance in Plasmodium falciparum malaria has emerged in western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. Using DNA microarrays we identify key features of a transcriptional profile that are associated with the delayed parasite clearance phenotype. These include reduced expression of several basic metabolic and cellular pathways in the early stages, and increased expression of essentially all functionalities associated with protein metabolism in the later stages of P. falciparum intraerythrocytic development. This is consistent with the reduced ring stage susceptibility that characterizes artemisinin resistant P. falciparum. This modulation of the P. falciparum intraerythrocytic transcriptome may result from differential expression of several regulatory proteins such as transcription factors of chromatin remodeling associated factors. In addition, the artemisinin resistant phenotype is strongly associated with a specific pattern of copy number variations, some of which are linked with differential expression of several regulatory proteins such as histone 4 and zinc permease. This study reports the first global transcriptional survey of artemisinin resistant parasites and provides a set of candidate genes for further investigation.

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2010-12-07 | E-GEOD-25878 | biostudies-arrayexpress

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

Project description:This SuperSeries is composed of the following subset Series: GSE25878: Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription (expression) GSE25879: Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription (CGH) Refer to individual Series

2010-12-07 | E-GEOD-25883 | biostudies-arrayexpress

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