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Epigenome analysis of normal skin and hypertrophic scar samples

ABSTRACT: Epigenome analysis of normal skin and hypertrophic scar samples

PROVIDER: PRJNA956447 | ENA |

REPOSITORIES: ENA

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Epigenome analysis of normal skin and hypertrophic scar samples

Project description:Hypertrophic scarring (HS) is characterized by excessive extracellular matrix deposition, matrix metalloprotein gene activation, and fibroblast invasive growth. However, the methylation level of hypertrophic scarring is poorly understood. Genome wide DNA methylation profiling of normal skin and hypertrophic scar. The Illumina Infinium Methylation EPIC BeadChip (850K) was used to obtain DNA methylation profiles across approximately 853,307 CpGs in liquid based scar samples. Samples included 6 normal skin, and 6 hypertrophic scar.

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The CD90+CD39+ and CD90+CD39- fibroblast subtypes in human hypertrophic scar and normal skin

Project description:To explore the functional difference between CD90+CD39+ and CD90+CD39- fibroblasts in human hypertrophic scar and normal skin, the gene expresson microarray was performed on Live CD49f- E-Cadherin- Lin- CD45- CD31- CD90+ CD39+ and Live CD49f- E-Cadherin- Lin- CD45- CD31- CD90+ CD39- cells sorted from suspension disgested from three human hypertrophic scar samples; and Live CD49f- E-Cadherin- Lin- CD45- CD31- CD90+ CD39+ cells sorted from suspension disgested from three human normal skin samples

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Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

Project description:Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

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Gene Expression in Three Early Human Hypertrophic Scar Samples

Project description:The goal was to obtain expression data from the deep cones in early human hypertrophic scars to be used to confirm expression data obtained in a porcine model. Three samples of early human hypertrophic scar were obtained and processed with the Affymetrix Human GeneChip® Human Genome U133 plus 2.0. Sample demographics were Black 2, White 1; upper extremity 2, neck 1; times since injury 6.7 months and 10.8 months; and patient ages were 19 and 54.

2011-12-31 | E-GEOD-26213 | biostudies-arrayexpress

Differential N6-methyladenosine(m6A) modification in hypertrophic scar v.s. normal skin

Project description:N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotes. Here, m6A-mRNA and lncRNA transcriptomes were profiled for HS and full-thickness normal skin (NS) tissues using human m6A-mRNA and lncRNA epitranscriptomic microarray. These data exhibited 5838 differentially m6A methylated transcripts (4706 mRNAs, 1132 lncRNAs) between HS and NS tissues. Of note, most of them (about 94%) were hypermethylated. And 3197 differentially expressed mRNAs (1466 upregulated and 1731 downregulated) were obtained by microarray. Conjoint analysis of differentially methylated and differentially expressed transcripts screened 815 transcripts (675 hyper-up, 140 hypo-down). Among them, IFNGR1 (ENST00000367739) and IL37 (ENST00000349806) are two of the most significant methylated transcripts in hyper-up and hypo-down groups. This study proposed a transcriptional regulatory network of m6A modifications on mRNA and lncRNA in human hypertrophic scar, which may bring a new clue into the development, pathogenesis, and treatment of abnormal scars.

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Lactylome and Proteome of Human Hypertrophic Scar Tissues

Project description:Here, using a label-free quantification approach, global lactylome and proteome analyses were performed based on 4 hypertrophic scar and 4 adjacent normal skin samples.

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RNA-seq of human hypertrophic scar fibroblast cell treated with fkbp10 siRNA against untreated controls

Project description:human hypertrophic scar fibroblast cell treated with fkbp10 siRNA and control siRNA for 48 hours

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RNA-seq of human hypertrophic scar fibroblast cell treated with pcolce siRNA against untreated controls

Project description:human hypertrophic scar fibroblast cell treated with pcolce siRNA and control siRNA for 48 hours

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The CD90+CD39+ and CD90+CD39- fibroblast subtypes in human hypertrophic scar and normal skin

Project description:The CD90+CD39+ and CD90+CD39- fibroblast subtypes in human hypertrophic scar and normal skin

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Microarray profiling analysis of microRNAs expression in Hypertrophic scar

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