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Trim2b mediates protection against SVCV infection by degrading NLRP12-like and viral SVCV-N/SVCV-G proteins

ABSTRACT: Trim2b mediates protection against SVCV infection by degrading NLRP12-like and viral SVCV-N/SVCV-G proteins

PROVIDER: PRJNA971593 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24511700_1.fastq.gz	Fastqsanger.gz
	SRR24511700_2.fastq.gz	Fastqsanger.gz
	SRR24511701_1.fastq.gz	Fastqsanger.gz
	SRR24511701_2.fastq.gz	Fastqsanger.gz
	SRR24511702_1.fastq.gz	Fastqsanger.gz

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Trim2b mediates protection against SVCV infection by degrading NLRP12-like and viral SVCV-N/SVCV-G proteins

Project description:In the present study, we report the functional characterization of zebrafish trim2b. we show that zebrafish trim2b plays a protective role in the host defense against SVCV infection. During SVCV infection, the in vivo studies revealed that trim2b overexpression led to the decreased virus loads and increased survival rate. Zebrafish trim2b deficiency led to the increased virus loads and decreased survival rate. In addition, Zebrafish trim2b deficiency leads higher numbers of immune related DEGs and signaling pathways enriched during the SVCV infection or uninfection. Among them, NOD-like receptor signaling pathway was significantly enriched. The present study characterized two NLRs degraded by trim2b plays a negative role in the host defense against SVCV infection.

2024-04-26 | GSE232313 | GEO

RNAseq analysis of gene expression in colorectal tumors of wild-type and Nlrp12-/- mice

Project description:Background: NLRP12 is a cytosolic pattern recognition receptor in the family of NOD-like receptor. NLRP12 has been shown to suppress colorectal tumorigenesis. However, the precise mechansim of NLRP12-mediated regualtion of colorectal cancer is unknown. Results: RNAseq data demonstrate higher expression of oncogenes, matrix degrading enzymes such as matrix metaloproteinases (MMPs), and genes involved in tumor invasion in Nlrp12-/- compared to wild-type tumors. Notably, several of the genes highly induced in Nlrp12-/- tumors are regulated by the Wnt/b-catenin pathway. Conclusion: NLRP12 negatively regualtes the Wnt/b-catenin pathway to suppress colorectal cancer progression and invasion.

2020-10-01 | GSE149769 | GEO

The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

Project description:Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice Four-conditions experiment, Nlrp12-deficient mouse infected by Citrobacter rodentium at day 7 versus non-infected Nlrp12-deficient mice with two biologicals replicates , Wild-type mouse infected by Citrobacter rodentium at day 7 versus non-infected Wild-type mice with two biologicals replicates and Nlrp12-deficient mouse infected by Citrobacter rodentium versus Control mouse infected by Citrobacter rodentium at 2 differents times ( day 0 and post infection at day 7 ) with three biologicals replicates

2015-07-25 | E-GEOD-59940 | biostudies-arrayexpress

The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

Project description:Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice

2015-07-25 | GSE59940 | GEO

Nlrp12

Project description:Rattus norvegicus Nlrp12, NLR family, pyrin domain containing 12 [Source:RGD Symbol;Acc:1309415], is differentially expressed in 1 experiment(s);

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Nlrp12

Project description:Rattus norvegicus Nlrp12, NLR family, pyrin domain containing 12 [Source:RGD Symbol;Acc:1309415], is expressed in 2 baseline experiment(s);

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NLRP12

Project description:Monodelphis domestica NLRP12, NLR family pyrin domain containing 12 [Source:NCBI gene;Acc:100018825], is expressed in 2 baseline experiment(s);

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Nlrp12

Project description:Mus musculus Nlrp12, NLR family, pyrin domain containing 12 [Source:MGI Symbol;Acc:MGI:2676630], is differentially expressed in 45 experiment(s);

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NLRP12

Project description:Homo sapiens NLRP12, NLR family pyrin domain containing 12 [Source:HGNC Symbol;Acc:HGNC:22938], is expressed in 28 baseline experiment(s);

| ENSG00000142405 | ExpressionAtlas

NLRP12

Project description:Sus scrofa NLRP12, NLR family pyrin domain containing 12 [Source:VGNC Symbol;Acc:VGNC:98519], is differentially expressed in 1 experiment(s);

| ENSSSCG00000003251 | ExpressionAtlas

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