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Combined Proteomics and Transcriptomics Identifies Serpin Family C Member 1 Associated Protein as a Biomarker of Endometriosis

ABSTRACT: Combined Proteomics and Transcriptomics Identifies Serpin Family C Member 1 Associated Protein as a Biomarker of Endometriosis

PROVIDER: PRJNA973632 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24630272_1.fastq.gz	Fastqsanger.gz
	SRR24630272_2.fastq.gz	Fastqsanger.gz
	SRR24630273_1.fastq.gz	Fastqsanger.gz
	SRR24630273_2.fastq.gz	Fastqsanger.gz
	SRR24630274_1.fastq.gz	Fastqsanger.gz

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Combined Proteomics and Transcriptomics Identifies Serpin Family C Member 1 Associated Protein as a Biomarker of Endometriosis

Project description:Objective: To explore potential biomarkers indicating endometriosis. Results: A sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the endometriosis cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e., fetuin B and serpin family C member 1; the latter showed a big variance between the control category and the EM set in the authentication test. Conclusion: Serpin family C member 1 may be a useful possible biomarker for the analysis of EM.

2023-05-22 | GSE232713 | GEO

Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis.

Project description:ObjectiveTo explore potential biomarkers indicating endometriosis (EM).Materials and methodsA proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay.ResultsA sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the EM cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e. fetuin B (FETUB) and serpin family C member 1 (SERPINC1); the latter showed a big variance between the control category and the EM set in the authentication test.ConclusionSERPINC1 may be a useful possible biomarker for the analysis of EM.

| S-EPMC10424617 | biostudies-literature

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