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Single-cell transcriptomic profling of the aging mouse choroid plexus

ABSTRACT: Single-cell transcriptomic profling of the aging mouse choroid plexus

PROVIDER: PRJNA973957 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24638757_1.fastq.gz	Fastqsanger.gz
	SRR24638757_2.fastq.gz	Fastqsanger.gz
	SRR24638758_1.fastq.gz	Fastqsanger.gz
	SRR24638758_2.fastq.gz	Fastqsanger.gz

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Single-cell transcriptomic profling of the aging mouse choroid plexus

Project description:The blood-cerebrospinal fluid (B-CSF) barrier in the choroid plexus (CP) consists of tight junctions between CP epithelial cells. It is critical to maintaining the environmental homeostasis of the central nervous system and is associated with age-related disorders, such as neurodegenerative diseases. Nevertheless, its ageing is poorly understood. This study collects CP from both young and aged mice for single-cell sequencing, aiming at elucidating the molecular mechanisms driving the age-dependent degeneration of the B-CSF barrier in CP.

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Project description:To examine the cellular and transcriptional heterogeneity of choroid plexus tumors we determined the single nucleus transcriptomes of 23,906 nuclei from normal choroid plexus and choroid plexus tumors. The resulting cellular atlas profiles cellular and transcriptional heterogeneity, copy number alterations, and cell-cell interaction networks in normal and cancerous choroid plexus. We observe changes in choroid plexus tumor epithelial cell gene transcription that correlate with genome wide methylation profiles. In addition, we characterize tumor-grade-specific tumor microenvironments that include altered macrophage and mesenchymal cell states, as well as changes in extracellular matrix components.

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