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TranscriptomicsMicroarray platform comparison study of hippocampal gene expression in DCLK1 transgenic and wild-type mice
The aim of the present study was to compare, on a statistical basis, the performance of different microarray platforms to detect differences in gene expression in a realistic and challenging biological setting. Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-dou...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8349 | biostudies-arrayexpress
TranscriptomicsSpecific Lineage differentiation of proepicardial explant cultures
The HH16/17 chicken proepicardium (PE) gives rise to the embryonic epicardium (Epi) which significantly contributes formation of the coronary vasculature during cardiac development. In contrast to explanted Epi cells, explanted PE cells can undergo differentiation into a cardiac myocyte phenotype. I...
ORGANISM(S): Gallus gallus 
2014-01-01 | E-GEOD-32508 | biostudies-arrayexpress
TranscriptomicsDivergent gene-expression profiles between proepicardium and epicardium differentiation
The HH16/17 chicken proepicardium (PE) gives rise to the embryonic epicardium (Epi) which significantly contributes formation of the coronary vasculature during cardiac development. In contrast to explanted Epi cells, explanted PE cells can undergo differentiation into a cardiac myocyte phenotype. I...
ORGANISM(S): Gallus gallus 
2010-12-21 | E-GEOD-13923 | biostudies-arrayexpress
GenomicsGenome-wide assessment of differential roles for p300 and CBP in transcription regulation
Through ChIP-Seq analysis with the Illumina Whole Genome Analyzer, we identify binding sites for P300 (EP300) and CBP (CREBBP) in Human glioblastoma T98G cells that were cell cycle synchronized before and after stimulation. In our analysis, we focused on the identification of genes differentially bo...
ORGANISM(S): Homo sapiens 
2010-03-30 | E-GEOD-21026 | biostudies-arrayexpress
TranscriptomicsExpression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter
The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV node-specific reporter mouse to gain insight into the gene programs determining the forma...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-13614 | biostudies-arrayexpress
TranscriptomicsRNA degradation in proliferating and differentiated C2C12 muscle precursor cells analyzed on Affymetrix exon arrays
Steady-state RNA levels are a result of RNA synthesis and degradation. The importance of transcription-factor mediated induction or repression of mRNA synthesis is well established, but the role and mechanisms of RNA degradation are less well understood. We globally evaluated the RNA decay rates in ...
ORGANISM(S): Mus musculus 
2010-09-22 | E-GEOD-14387 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in embryonic chicken heart
MicroRNAs are small non-coding RNA transcripts that regulate post-transcriptional gene expression. The millions of short sequence reads generated by next generation sequencing technologies make this technique explicitly suitable for profiling of known and novel microRNAs. A modification to the small...
ORGANISM(S): Gallus gallus 
2010-12-21 | E-GEOD-20757 | biostudies-arrayexpress
TranscriptomicsHigh throughput sequencing of the hippocampal transcriptome of wild type and DCLK-short over-expressing mice
Comparative gene expression analysis by deep sequencing of the hippocampal transcriptome of wild-type and DCLK-short overexpressing mice with Illumina/Solexa digital gene expression assay
ORGANISM(S): Mus musculus 
2008-12-01 | E-MTAB-71 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between left and right chicken HH14 sinus horns
Microarrays experiments were performed in order to assess which genes are differentially expressed between the embryonic chicken sinus horns at HH14. Three, technical, dye swapped comparisons between Left and Right sinus horns. In total six arrays were used in this study
ORGANISM(S): Gallus gallus 
2013-05-01 | E-GEOD-16433 | biostudies-arrayexpress
TranscriptomicsIncreased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and highly informative expression profiling data, with several million of ...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33701 | biostudies-arrayexpress
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