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MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
GenomicsMitochondrial cristae architecture protects against mtDNA release and inflammation
Mitochondrial cristae architecture protects against mtDNA release and inflammation
PRJNA894105 | ENA
ProteomicsDiverged Trypanosome MICOS as a Hub for Mitochondrial Cristae Shaping and Protein Import
The mitochondrial contact site and cristae organization system (MICOS) is a complex responsible for proper cristae formation. Empirical data about this ubiquitous complex is limited to opisthokont models (e.g. yeast), impeding understanding of its core properties and adaptation potential to diverse ...
ORGANISM(S): Trypanosoma brucei 
2018-09-13 | PXD009601 | Pride
Mitochondria  cristae  intermembrane space  micos  protein import  trypanosoma brucei  lc-ms/ms  label-free  tmt 
TranscriptomicsTranscription profiling of rat hair and supporting cells from the cristae ampullaris in the inner ear
Using laser capture microdisection, the more superficial layer of the cristae ampullaris sensory epithelium encompassing types I and II hair cells, and the supporting cell cytoplasm interspersed between them was captured in the first pass, and the underlying supporting cell bodies resting on the bas...
ORGANISM(S): Rattus norvegicus 
2008-05-01 | E-MEXP-1559 | biostudies-arrayexpress
TranscriptomicsMitochondrial cristae architecture protects against mtDNA release and inflammation
Mitochondrial damage causes mtDNA release to activate type I interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation promotes autoimmune and aging-related degenerative disorders. However, the global picture of inflammation-inducing mitochondrial damages remains obscure. He...
ORGANISM(S): Mus musculus 
2022-10-28 | GSE216499 | GEO
TranscriptomicsIdentification of microRNA targets in the mammalian inner ear using a comprehensive transcriptome and proteome integrated approach
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions using integrated miRNA, transcriptome and proteome profiles with advanced in silico analysis. By looking at both the transcript and protein levels of expression, a thorough coverag...
ORGANISM(S): Mus musculus 
2011-04-20 | E-GEOD-23081 | biostudies-arrayexpress
GenomicsMIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease
MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease
PRJNA1380424 | ENA
ProteomicsArg1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
Ischemic/hypoxic injury significantly damages vascular function, detrimentally im-pact-ing patient outcomes. Changes in mitochondrial structure and function are closely associated with ischemia/hypoxia-induced vascular dysfunction. The mecha-nism of this process remains elusive. Using rat models of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-02 | PXD063156 | Pride
Mtdna Ischemic/hypoxic injury Mitochondria Vascular dysfunction Arg1 
UnknownCristae dynamics is modulated in bioenergetically compromised mitochondria.
Not available
S-EPMC10643176 | biostudies-literature
UnknownLive-cell STED nanoscopy of mitochondrial cristae.
Not available
S-EPMC6712041 | biostudies-literature
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