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TranscriptomicsTranscriptional response of Schizosaccharomyces pombe to 5-Fluorouracil (5FU)
We use high-density tiling DNA microarray technology to obtain the specific transcriptome-wide response induced by 5-Fluorouracil (5FU) in the eukaryotic model Schizosaccharomyces pombe. Schizosaccharomyces pombe cultures with 5FU added to a final concentration of 500 M-NM-
ORGANISM(S): Schizosaccharomyces pombe 
2013-11-14 | E-GEOD-46919 | biostudies-arrayexpress
TranscriptomicsSynergistic effects of 5-Fluorouracil in combination with Salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in Colorectal Cancer
Purpose: 5-FU resistance is considered to be a possible reason for the failure of conventional drug treatment of colorectal cancer (CRC). Recently, salinomycin (SAL), as a selective inhibitor of cancer stem cells (CSCs), has been used to sensitize and attenuate a variety of solid tumor chemotherapy ...
ORGANISM(S): Homo sapiens 
2025-06-21 | E-MTAB-15206 | biostudies-arrayexpress
TranscriptomicsGene expression patterns induced by 5-Fluorouracil in breast cancer cell lines
We have compared the changes in cell cycle and cell death parameters induced by 2 different concentrations of 5-FU (IC50 and IC80) in the breast adenocarcinoma cell line MCF7. G1/S cell cycle arrest was associated with both concentrations, whereas cell death was mainly induced after IC80 5-FU. These...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2584 | biostudies-arrayexpress
ProteomicsThe Effects of 5-Fluorouracil/Leucovorin Chemotherapy on Cognitive Function in Mice
5-Fluorouracil (5-Fu) and leucovorin (LV) are often given in combination to treat colorectal cancer. 5-Fu/LV prevents cell proliferation by inhibiting thymidylate synthase, which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. While 5-Fu has been shown to caus...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD028899 | Pride
Neurovasculature Hippocampus 5-fluorouracil 
ProteomicsIMPRINTS-CETSA, 5-FU in parental and 5-FU-resistant HCT15 cells
Parental and 5-fluorouracil (5-FU)-resistant HCT15 cells were treated with 5-FU or vehicle for 12h and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobar...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026472 | JPOST Repository
TranscriptomicsComparative genomic hybridization of strains of Leishmania infantum wild-type and five independent 5-fluorouracil resistant mutant.
The genomic DNAs of strains 263 of L. infantum and five derived independent resistant mutants to 5-fluorouracil were used in comparative genomic hybridizations to reveal the deletion and/or amplification events occured by drug resistance mechanisms. The human protozoan parasites Leishmania are proto...
ORGANISM(S): Leishmania infantum 
2013-12-31 | E-GEOD-45866 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling for prediction of chemoradiation efficacy in locally advanced head and neck squamous cell carcinoma
The predictive value of microRNAs for the efficacy of chemoradiation (CRTX) in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated. Formalin-fixed, paraffin-embedded tumor material was collected from patients with locally advanced HNSCC treated within the ARO-0401 phase III ...
ORGANISM(S): Homo sapiens 
2017-03-30 | E-MTAB-5198 | biostudies-arrayexpress
TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
Proteomics5-fluorouracil (5-Fu) resistant Bel/5Fu cell line and its parent Bel7402 cell line
The extensive drug resistance of hepatocellular carcinoma (HCC) has become the main cause of chemotherapy failure. The mechanisms leading to drug resistance in tumor cells are not well understood. Previous studies demonstrated that plasma membrane proteins play important roles in mediating drug disp...
ORGANISM(S): Homo Sapiens 
2019-10-19 | PXD015917 |
ProteomicsNovel mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer: A Proteomic Investigation
One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU), the most commonly used drug in CRC patients. Whilst some mechanisms of resistance are well-known, it is clear from the stasis i...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047672 | Pride
Colorectal cancer  drug resistance mechanisms  in vitro models  proteomics  5-fluorouracil  stable isotope labelling with amino acids in cell culture (silac) 
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