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ProteomicsIdentification of proteins specifically binding to ac4C RNA probes
As a newly identified mRNA modification, the regulation of ac4C remains largely unexplored. RNA-binding proteins (RBPs) that specifically binds to ac4C modification and mediate downstream cellular activities (readers) have not been reported yet. We synthesized acetylated and non-acetylated RNA probe...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD027014 | Pride
Rna pulldown Ac4c Acetylated rna probes 
Genomicschemical ac4C sequencing (ac4C-seq) to identify mRNA ac4C sites
chemical ac4C sequencing (ac4C-seq) to identify mRNA ac4C sites
PRJNA941322 | ENA
Genomicsac4C-RIP-seq to identify mRNA ac4C peaks
ac4C-RIP-seq to identify mRNA ac4C peaks
PRJNA941324 | ENA
ProteomicsNAT10-mediated ac4C-modification exacerbates ferroptosis by stabilizing HMOX1 in Deep vein thrombosis
In our study, we aimed to identify the pathways and genes closely related to DVT. Through proteomic analysis, we found that the ferroptosis signaling pathway showed differential expression, and we also discovered that NAT10 (a key acetyltransferase modified by ac4C) was significantly overexpressed i...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD067933 | Pride
Deep venous thrombosis  nat10  ac4c  hmox1  ferroptosis 
GenomicsNAT10-ac4C axis promote renal fibrosis
NAT10-ac4C axis promote renal fibrosis
PRJNA1042804 | ENA
Genomicsac4C transcriptomes of Zebrafish and Worm
ac4C transcriptomes of Zebrafish and Worm
PRJNA1130538 | ENA
Genomicsac4C in regulation of gene expression
ac4C in regulation of gene expression
PRJNA1085243 | ENA
ProteomicsNAT10-dependent N4-acetylcytidine (ac4C) reprograms R-loops and promotes cancer stem cell growth
R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we found that glioblastoma (GBM) stem cells (GSCs) display highly active R-loops compared to differentiated tumor ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD077002 | Pride
Ac4c Cancer stem cell Nat10 Glioblastoma R-loop remodeling Glioblastoma stem cell 
Otherchemical ac4C sequencing (ac4C-seq) to identify mRNA ac4C sites
NAT10-catalyzed N4-acetylcytidine (ac4C) has emerged as a vital post-transcriptional modulator on the coding transcriptome by promoting mRNA stability. To explore the transcriptome-wide profile of ac4C modification, we mapped the locations of ac4C modification on wild-type (WT) hESCs and NAT10 KD hE...
ORGANISM(S): Homo sapiens 
2023-08-25 | GSE226747 | GEO
Genomicsac4C-seq in NAT10-knockdown PANC-1 cells
ac4C-seq in NAT10-knockdown PANC-1 cells
PRJNA1153970 | ENA
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