activation of complement system

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Organisms

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Organisms

Mus musculus (32)
Homo sapiens (23)
Sus scrofa (3)
Rattus norvegicus (3)
Papio cynocephalus (1)
Carassius gibelio (1)
Duncanopsammia peltata (1)
Mustela putorius furo (1)
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Technology Type

Mass Spectrometry (125)
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Chemical cross-linking coupled with mass spectrometry proteomics (5)
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Affinity purification coupled with mass spectrometry proteomics (2)
All-ion fragmentation (2)

Instrument Platform

Illumina NovaSeq 6000 (23)
Illumina HiSeq 4000 (11)
Illumina HiSeq 2500 (7)
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Q Exactive (7)
Illumina NovaSeq X (5)
Agilent High resolution C scanner (4)
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Qiagen RNEasy Mini ki (1)
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Illumina MiSeq (1)
- (1)

Publication Date

2010 (68)
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2013 (48)
2022 (42)
2016 (40)
2023 (39)
2012 (39)
2014 (37)
2026 (36)
2011 (35)
2015 (33)
2024 (30)
2008 (29)
2020 (24)
2021 (21)
2009 (19)
2018 (18)
2007 (18)
2019 (15)
2017 (15)
2006 (10)
2005 (4)
2004 (2)
2003 (1)

UNIPROT ID/AC

P04003 (1)
Q15485 (1)
O00187 (1)
P01024 (1)
P06681 (1)
P0C0L4 (1)
P0C0L5 (1)
P02741 (1)
P08646 (1)
Q504U8 (1)
P61981 (1)
P62714 (1)
P30086 (1)
Q91854 (1)
A4F2Q1 (1)
O00512 (1)
O60264 (1)
P45481 (1)
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Q8UVT6 (1)
P67870 (1)
P68400 (1)
P54367 (1)
O75197 (1)
O75581 (1)
P18537 (1)
P17252 (1)
P35222 (1)
P49841 (1)

CHEBI ID

CHEBI:15428 (4)
CHEBI:16958 (4)
CHEBI:16335 (4)
CHEBI:15891 (4)
CHEBI:16704 (4)
CHEBI:18012 (4)
CHEBI:16919 (4)
CHEBI:17596 (4)
CHEBI:17368 (4)
CHEBI:18132 (3)
CHEBI:17822 (3)
CHEBI:15721 (3)
CHEBI:15846 (3)
CHEBI:18237 (3)
CHEBI:17126 (3)
CHEBI:18257 (3)
CHEBI:16708 (3)
CHEBI:17562 (3)
CHEBI:16977 (3)
CHEBI:17924 (3)
CHEBI:17148 (3)
CHEBI:37654 (3)
CHEBI:16610 (3)
CHEBI:114785 (1)
CHEBI:25750 (1)
CHEBI:506227 (1)
CHEBI:15996 (1)
CHEBI:17552 (1)
CHEBI:15422 (1)
CHEBI:16761 (1)

Metabolite Name

Uridine (3)
Taurine (3)
Inosine (3)
Hypoxanthine (3)
Cytidine (3)
Adenine (3)
Creatine (3)
Adenosine (3)
4-quinolinecarboxylic acid (2)
Valylleucine (2)
Gamma-glutamylcysteine (2)
3-amino-2-piperidone (2)
3-formylindole (2)
Glycerophosphoserine* (2)
Isocitric lactone (2)
1-oleoyl-2-linoleoyl-GPE (18:1/18:2)* (2)
2-hydroxybutyrate/2-hydroxyisobutyrate (2)
N-acetylglucosamine/N-acetylgalactosamine (2)
Ribulose/xylulose (2)
Fructosyllysine (2)
Mannonate* (2)
Phenylalanylalanine (2)
Phenylalanylglycine (2)
UDP-N-acetylglucosamine/galactosamine (2)
2-oxoarginine* (2)
Sedoheptulose (2)
2,4-dihydroxybutyrate (2)
Alanylleucine (2)
Methylphosphate (2)
Sedoheptulose-7-phosphate (2)

First Public Date

2014 (14)
2026 (12)
2025 (12)
2023 (8)
2021 (8)
2022 (6)
2019 (6)
2024 (5)
2020 (3)
2018 (3)
2013 (3)
2017 (2)
2016 (1)
2015 (1)

Modelling Approach

Ordinary differential equation model (8)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (3)
1. Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, UK 2. Department of Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, Germany (2)
Aarhus University Department of Biomedicine DK-8000 Aarhus C (2)
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA (2)
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil (2)
Transplantation laboratory, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland (2)
Aging $ Metabolism, Gene Translation Laboratory, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain. (1)
Alborg University (1)
Associate Professor Director of Proteomics and Mass Spectrometry Facility School of Biological Sciences Nanyang Technological University 60 Nanyang Drive, Singapore 637551 Tel: (65) 6514-1006; Fax: (65) 6791-3856 Email: sksze@ntu.edu.sg Web: http://proteomics.sbs.ntu.edu.sg/ (1)
Associate Professor of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Germany (1)
Bertis R&D Division, Bertis Inc., Republic of Korea (1)
Biobanking Group, Branch Of IBMC "Scientific and Educactional Center" (1)
Bioheat and mass transfer laboratory, Med-X Research Institute, Shanghai Jiao Tong University (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine, University of Piemonte Orientale (1)
Biology Department University of Wisconsin-La Crosse 1725 State St. La Crosse, WI 54601 USA (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences,University of Utrecht (1)
CAS Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. (1)
CSIC/UAB Proteomics Facility. IIBB-CSIC, IDIBAPS. Barcelona, Spain. (1)
Center for Addiction Research Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77555 (1)
Center for Proteomics and Metabolomics, LUMC, Leiden, The Netherlands (1)
Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands (1)
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital, University of Zurich, Zurich, Switzerland (1)
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada (1)
Centre of International Health, Department of Global Public Health and Primary Care, University of Bergen, Norway (1)
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, PR China (1)
DEPARTMENT OF TROPICAL MEDICINE,SCHOOL OF TROPICAL MEDICINE, KOLKATA, WEST BENGAL, INDIA (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark (1)

IsPrivate

False (8)

Classification

bacteria (1)

Modification

-17.026549 (1)
-18.010565 (1)
15.994915 (1)
42.010565 (1)
57.021464 (1)
79.966331 (1)

Study type

Transcription profiling by array (270)
RNA-seq of coding RNA (58)
Unknown experiment type (10)
RNA-seq of coding RNA from single cells (8)
Comparative genomic hybridization by array (7)
Transcription profiling by tiling array (5)
Genotyping by array (5)
Other (5)
Proteomic profiling by array (5)
RNA-seq of total RNA (5)
ChIP-seq (4)
Animal - One-color microarray (3)
RNA-seq of non coding RNA (3)
ChIP-chip by tiling array (2)
Human - High-throughput sequencing (2)
Animal - High-throughput sequencing (2)
Transcription profiling by RT-PCR (2)
MicroRNA profiling by high throughput sequencing (2)
DNA-seq (2)
Methylation profiling by array (2)
Transcription profiling by SAGE (1)
Differential (1)
Human - One-color microarray (1)
Trajectory (1)
Capture-C (1)
Spatial transcriptomics by high-throughput sequencing (1)
Hi-C (1)
MicroRNA profiling by array (1)
CUT&RUN (1)

Release Date

2022 (185)
2023 (156)
2021 (144)
2025 (139)
2020 (129)
2024 (109)
2018 (106)
2019 (92)
2010 (86)
2014 (84)
2012 (81)
2015 (73)
2016 (70)
2013 (70)
2017 (64)
2011 (62)
2008 (37)
2026 (36)
2009 (33)
2007 (29)
2006 (12)
2005 (7)
2004 (3)
2000 (3)
2003 (1)
2001 (1)
1999 (1)
1997 (1)

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Repeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway

Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...

ORGANISM(S): Mus musculus

2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress

A Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients

Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated im...

2022-01-18 | MTBLS2469 | MetaboLights

Targeted MRM assay Complement System in Health and Infectious Disease

The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...

ORGANISM(S): Homo Sapiens

PXD014264 | panorama

Proteomic Analyses of Plasma from Patients with Fracture Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades

Patients/Participants: Twenty-seven patients meeting confirmatory FRI criteria were matched to 27 controls based on fracture region, age, and time after surgery Intervention: Tandem Mass Tag (TMT) LC-MS analysis of patient plasma samples Main Outcome Measurements: Abundances for over 1000 proteins w...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-10-15 | MSV000093116 | MassIVE

Urine complement analysis implies complement activation is involved in membranous nephropathy

Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinar...

ORGANISM(S): Homo Sapiens

2025-02-01 | PXD060494 |

The alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression

Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...

ORGANISM(S): Mus musculus

2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress

Bakshi2020 - Truncated minimal model of alternative pathway of complement system

This model is based on the publication: "Mathematical Modelling of Alternative Pathway of Complement System". Suruchi Bakshi, Fraser Cunningham, Eva-Maria Nichols, Marta Biedzka-Sarek, Jessica Neisen, Sebastien Petit-Frere, Christina Bessant, Loveleena Bansal, Lambertus A Peletier, Stefano Zamuner, ...

2024-09-02 | BIOMD0000001016 | BioModels

Complement activation by AAV-neutralizing antibody complexes

IP-MS analysis of AAV9 empty capsid protein-protein interactions with serum from healthy human donors.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-03-09 | MSV000091454 | MassIVE

Bakshi2020 - Minimal model of alternative pathway of complement system

2024-09-02 | BIOMD0000001017 | BioModels

Bakshi2020 - Properdin model of alternative pathway of complement system

2024-09-02 | BIOMD0000001018 | BioModels