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ProteomicsAn affinity-directed phosphatase (AdPhosphatase) system for targeted protein dephosphorylation
Reversible protein phosphorylation, catalysed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signalling. Failure of phospho-control accounts for many human diseases. While a kinase phosphorylates multiple substrates, a substrate is o...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD039200 | Pride
Affinity-directed phosphatase  adphosphatase  targeted dephosphorylation  ppp1ca ppp2ca  nanobody  ulk1  fam83d 
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053308 | Pride
Bdpic Ppp2ca Tfeb Adphosphatase Phostac 
UnknownTargeted dephosphorylation of TFEB promotes its nuclear translocation.
Not available
S-EPMC11284556 | biostudies-literature
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053311 | Pride
Adphosphotase Dephosphorylation Bdpic Ppp2ca Tfeb Phostac 
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